Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

HER2 acts an oncogenic driver in numerous cancers. Here, the authors design an anti-HER2 biparatopic and tetravalent IgG fusion with inhibitory effects in a xenograft model.

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Detalles Bibliográficos
Autores principales: Florian Kast, Martin Schwill, Jakob C. Stüber, Svende Pfundstein, Gabriela Nagy-Davidescu, Josep M. Monné Rodríguez, Frauke Seehusen, Christian P. Richter, Annemarie Honegger, Karen Patricia Hartmann, Thomas G. Weber, Felix Kroener, Patrick Ernst, Jacob Piehler, Andreas Plückthun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/bbc4cba63fcc425a86335df0941f73d7
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https://doaj.org/article/bbc4cba63fcc425a86335df0941f73d7

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