Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host
Abstract Telomestatin, a strong telomerase inhibitor with G-quadruplex stabilizing activity, is a potential therapeutic agent for treating cancers. Difficulties in isolating telomestatin from microbial cultures and in chemical synthesis are bottlenecks impeding the wider use. Therefore, improvement...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/bc74afa0add84c29833f93ffbe2a2b0d |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|