Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

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Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

ABSTRACT Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics. Chlorpromazine and amitriptyline have been shown to behave as efflux inhibitors. However, their m...

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Auteurs principaux:	Elizabeth M. Grimsey, Chiara Fais, Robert L. Marshall, Vito Ricci, Maria Laura Ciusa, Jack W. Stone, Alasdair Ivens, Giuliano Malloci, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2020
Sujets:	antibiotic resistance efflux pump inhibitors AcrB antipsychotic drugs efflux pumps Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/c0b86e8c528248f1b64fee868c1d93ae
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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