SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.

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Auteurs principaux: Shuofeng Yuan, Hin Chu, Jasper Fuk-Woo Chan, Zi-Wei Ye, Lei Wen, Bingpeng Yan, Pok-Man Lai, Kah-Meng Tee, Jingjing Huang, Dongdong Chen, Cun Li, Xiaoyu Zhao, Dong Yang, Man Chun Chiu, Cyril Yip, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kong-Hung Sze, Jie Zhou, Ivy Hau-Yee Chan, Kin-Hang Kok, Kelvin Kai-Wang To, Richard Yi-Tsun Kao, Johnson Yiu-Nam Lau, Dong-Yan Jin, Stanley Perlman, Kwok-Yung Yuen
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/c1c5fe348ab54b8eb38874751717d9b6
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spelling oai:doaj.org-article:c1c5fe348ab54b8eb38874751717d9b62021-12-02T17:02:12ZSREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target10.1038/s41467-018-08015-x2041-1723https://doaj.org/article/c1c5fe348ab54b8eb38874751717d9b62019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08015-xhttps://doaj.org/toc/2041-1723Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.Shuofeng YuanHin ChuJasper Fuk-Woo ChanZi-Wei YeLei WenBingpeng YanPok-Man LaiKah-Meng TeeJingjing HuangDongdong ChenCun LiXiaoyu ZhaoDong YangMan Chun ChiuCyril YipVincent Kwok-Man PoonChris Chung-Sing ChanKong-Hung SzeJie ZhouIvy Hau-Yee ChanKin-Hang KokKelvin Kai-Wang ToRichard Yi-Tsun KaoJohnson Yiu-Nam LauDong-Yan JinStanley PerlmanKwok-Yung YuenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shuofeng Yuan
Hin Chu
Jasper Fuk-Woo Chan
Zi-Wei Ye
Lei Wen
Bingpeng Yan
Pok-Man Lai
Kah-Meng Tee
Jingjing Huang
Dongdong Chen
Cun Li
Xiaoyu Zhao
Dong Yang
Man Chun Chiu
Cyril Yip
Vincent Kwok-Man Poon
Chris Chung-Sing Chan
Kong-Hung Sze
Jie Zhou
Ivy Hau-Yee Chan
Kin-Hang Kok
Kelvin Kai-Wang To
Richard Yi-Tsun Kao
Johnson Yiu-Nam Lau
Dong-Yan Jin
Stanley Perlman
Kwok-Yung Yuen
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
description Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.
format article
author Shuofeng Yuan
Hin Chu
Jasper Fuk-Woo Chan
Zi-Wei Ye
Lei Wen
Bingpeng Yan
Pok-Man Lai
Kah-Meng Tee
Jingjing Huang
Dongdong Chen
Cun Li
Xiaoyu Zhao
Dong Yang
Man Chun Chiu
Cyril Yip
Vincent Kwok-Man Poon
Chris Chung-Sing Chan
Kong-Hung Sze
Jie Zhou
Ivy Hau-Yee Chan
Kin-Hang Kok
Kelvin Kai-Wang To
Richard Yi-Tsun Kao
Johnson Yiu-Nam Lau
Dong-Yan Jin
Stanley Perlman
Kwok-Yung Yuen
author_facet Shuofeng Yuan
Hin Chu
Jasper Fuk-Woo Chan
Zi-Wei Ye
Lei Wen
Bingpeng Yan
Pok-Man Lai
Kah-Meng Tee
Jingjing Huang
Dongdong Chen
Cun Li
Xiaoyu Zhao
Dong Yang
Man Chun Chiu
Cyril Yip
Vincent Kwok-Man Poon
Chris Chung-Sing Chan
Kong-Hung Sze
Jie Zhou
Ivy Hau-Yee Chan
Kin-Hang Kok
Kelvin Kai-Wang To
Richard Yi-Tsun Kao
Johnson Yiu-Nam Lau
Dong-Yan Jin
Stanley Perlman
Kwok-Yung Yuen
author_sort Shuofeng Yuan
title SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_short SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_full SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_fullStr SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_full_unstemmed SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_sort srebp-dependent lipidomic reprogramming as a broad-spectrum antiviral target
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/c1c5fe348ab54b8eb38874751717d9b6
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