SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.

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Autores principales:	Shuofeng Yuan, Hin Chu, Jasper Fuk-Woo Chan, Zi-Wei Ye, Lei Wen, Bingpeng Yan, Pok-Man Lai, Kah-Meng Tee, Jingjing Huang, Dongdong Chen, Cun Li, Xiaoyu Zhao, Dong Yang, Man Chun Chiu, Cyril Yip, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kong-Hung Sze, Jie Zhou, Ivy Hau-Yee Chan, Kin-Hang Kok, Kelvin Kai-Wang To, Richard Yi-Tsun Kao, Johnson Yiu-Nam Lau, Dong-Yan Jin, Stanley Perlman, Kwok-Yung Yuen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1c5fe348ab54b8eb38874751717d9b6
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spelling	oai:doaj.org-article:c1c5fe348ab54b8eb38874751717d9b62021-12-02T17:02:12ZSREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target10.1038/s41467-018-08015-x2041-1723https://doaj.org/article/c1c5fe348ab54b8eb38874751717d9b62019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08015-xhttps://doaj.org/toc/2041-1723Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.Shuofeng YuanHin ChuJasper Fuk-Woo ChanZi-Wei YeLei WenBingpeng YanPok-Man LaiKah-Meng TeeJingjing HuangDongdong ChenCun LiXiaoyu ZhaoDong YangMan Chun ChiuCyril YipVincent Kwok-Man PoonChris Chung-Sing ChanKong-Hung SzeJie ZhouIvy Hau-Yee ChanKin-Hang KokKelvin Kai-Wang ToRichard Yi-Tsun KaoJohnson Yiu-Nam LauDong-Yan JinStanley PerlmanKwok-Yung YuenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuofeng Yuan Hin Chu Jasper Fuk-Woo Chan Zi-Wei Ye Lei Wen Bingpeng Yan Pok-Man Lai Kah-Meng Tee Jingjing Huang Dongdong Chen Cun Li Xiaoyu Zhao Dong Yang Man Chun Chiu Cyril Yip Vincent Kwok-Man Poon Chris Chung-Sing Chan Kong-Hung Sze Jie Zhou Ivy Hau-Yee Chan Kin-Hang Kok Kelvin Kai-Wang To Richard Yi-Tsun Kao Johnson Yiu-Nam Lau Dong-Yan Jin Stanley Perlman Kwok-Yung Yuen SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
description	Viruses rely on host cell metabolism for replication, making these pathways potential therapeutic targets. Here, the authors show that AM580, a retinoid derivative and RAR-α agonist, affects replication of several RNA viruses by interfering with the activity of SREBP.
format	article
author	Shuofeng Yuan Hin Chu Jasper Fuk-Woo Chan Zi-Wei Ye Lei Wen Bingpeng Yan Pok-Man Lai Kah-Meng Tee Jingjing Huang Dongdong Chen Cun Li Xiaoyu Zhao Dong Yang Man Chun Chiu Cyril Yip Vincent Kwok-Man Poon Chris Chung-Sing Chan Kong-Hung Sze Jie Zhou Ivy Hau-Yee Chan Kin-Hang Kok Kelvin Kai-Wang To Richard Yi-Tsun Kao Johnson Yiu-Nam Lau Dong-Yan Jin Stanley Perlman Kwok-Yung Yuen
author_facet	Shuofeng Yuan Hin Chu Jasper Fuk-Woo Chan Zi-Wei Ye Lei Wen Bingpeng Yan Pok-Man Lai Kah-Meng Tee Jingjing Huang Dongdong Chen Cun Li Xiaoyu Zhao Dong Yang Man Chun Chiu Cyril Yip Vincent Kwok-Man Poon Chris Chung-Sing Chan Kong-Hung Sze Jie Zhou Ivy Hau-Yee Chan Kin-Hang Kok Kelvin Kai-Wang To Richard Yi-Tsun Kao Johnson Yiu-Nam Lau Dong-Yan Jin Stanley Perlman Kwok-Yung Yuen
author_sort	Shuofeng Yuan
title	SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_short	SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_full	SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_fullStr	SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_full_unstemmed	SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
title_sort	srebp-dependent lipidomic reprogramming as a broad-spectrum antiviral target
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c1c5fe348ab54b8eb38874751717d9b6
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SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

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