Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstrate its selectivity for the fungal enzyme, both bi...
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Nature Portfolio
2019
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oai:doaj.org-article:c204109fbee74209af84981ef754b8a62021-12-02T15:36:03ZStructural basis for species-selective targeting of Hsp90 in a pathogenic fungus10.1038/s41467-018-08248-w2041-1723https://doaj.org/article/c204109fbee74209af84981ef754b8a62019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08248-whttps://doaj.org/toc/2041-1723The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstrate its selectivity for the fungal enzyme, both biochemically and in cells.Luke WhitesellNicole RobbinsDavid S. HuangCatherine A. McLellanTanvi Shekhar-GuturjaEmmanuelle V. LeBlancCatherine S. NationRaymond HuiAshley HutchinsonCathy CollinsSharanya ChatterjeeRichard TrillesJinglin L. XieDamian J. KrysanSusan LindquistJohn A. PorcoUtpal TatuLauren E. BrownJuan PizarroLeah E. CowenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Luke Whitesell Nicole Robbins David S. Huang Catherine A. McLellan Tanvi Shekhar-Guturja Emmanuelle V. LeBlanc Catherine S. Nation Raymond Hui Ashley Hutchinson Cathy Collins Sharanya Chatterjee Richard Trilles Jinglin L. Xie Damian J. Krysan Susan Lindquist John A. Porco Utpal Tatu Lauren E. Brown Juan Pizarro Leah E. Cowen Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus |
| description |
The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstrate its selectivity for the fungal enzyme, both biochemically and in cells. |
| format |
article |
| author |
Luke Whitesell Nicole Robbins David S. Huang Catherine A. McLellan Tanvi Shekhar-Guturja Emmanuelle V. LeBlanc Catherine S. Nation Raymond Hui Ashley Hutchinson Cathy Collins Sharanya Chatterjee Richard Trilles Jinglin L. Xie Damian J. Krysan Susan Lindquist John A. Porco Utpal Tatu Lauren E. Brown Juan Pizarro Leah E. Cowen |
| author_facet |
Luke Whitesell Nicole Robbins David S. Huang Catherine A. McLellan Tanvi Shekhar-Guturja Emmanuelle V. LeBlanc Catherine S. Nation Raymond Hui Ashley Hutchinson Cathy Collins Sharanya Chatterjee Richard Trilles Jinglin L. Xie Damian J. Krysan Susan Lindquist John A. Porco Utpal Tatu Lauren E. Brown Juan Pizarro Leah E. Cowen |
| author_sort |
Luke Whitesell |
| title |
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus |
| title_short |
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus |
| title_full |
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus |
| title_fullStr |
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus |
| title_full_unstemmed |
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus |
| title_sort |
structural basis for species-selective targeting of hsp90 in a pathogenic fungus |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/c204109fbee74209af84981ef754b8a6 |
| work_keys_str_mv |
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| _version_ |
1718386379001430016 |