A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

The Parkinson’s disease‐associated LRRK2 protein is a multidomain Roco protein with GTPase activity. Here the authors use a multidisciplinary approach to characterize the GTPase mechanism of a homologous bacterial Roco protein and give mechanistic insights into disease-causing LRRK2 mutations.

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Auteurs principaux: Egon Deyaert, Lina Wauters, Giambattista Guaitoli, Albert Konijnenberg, Margaux Leemans, Susanne Terheyden, Arsen Petrovic, Rodrigo Gallardo, Laura M. Nederveen-Schippers, Panagiotis S. Athanasopoulos, Henderikus Pots, Peter J. M. Van Haastert, Frank Sobott, Christian Johannes Gloeckner, Rouslan Efremov, Arjan Kortholt, Wim Versées
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
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Accès en ligne:https://doaj.org/article/c26addf391a34197a5007b5002985a38
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Internet

https://doaj.org/article/c26addf391a34197a5007b5002985a38

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