Programming mRNA decay to modulate synthetic circuit resource allocation

Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.

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Bibliographic Details
Main Authors:	Ophelia S. Venturelli, Mika Tei, Stefan Bauer, Leanne Jade G. Chan, Christopher J. Petzold, Adam P Arkin
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/c43786f35a0d4d08ac93c75c2b65d83c
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spelling	oai:doaj.org-article:c43786f35a0d4d08ac93c75c2b65d83c2021-12-02T14:41:10ZProgramming mRNA decay to modulate synthetic circuit resource allocation10.1038/ncomms151282041-1723https://doaj.org/article/c43786f35a0d4d08ac93c75c2b65d83c2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15128https://doaj.org/toc/2041-1723Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.Ophelia S. VenturelliMika TeiStefan BauerLeanne Jade G. ChanChristopher J. PetzoldAdam P ArkinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ophelia S. Venturelli Mika Tei Stefan Bauer Leanne Jade G. Chan Christopher J. Petzold Adam P Arkin Programming mRNA decay to modulate synthetic circuit resource allocation
description	Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.
format	article
author	Ophelia S. Venturelli Mika Tei Stefan Bauer Leanne Jade G. Chan Christopher J. Petzold Adam P Arkin
author_facet	Ophelia S. Venturelli Mika Tei Stefan Bauer Leanne Jade G. Chan Christopher J. Petzold Adam P Arkin
author_sort	Ophelia S. Venturelli
title	Programming mRNA decay to modulate synthetic circuit resource allocation
title_short	Programming mRNA decay to modulate synthetic circuit resource allocation
title_full	Programming mRNA decay to modulate synthetic circuit resource allocation
title_fullStr	Programming mRNA decay to modulate synthetic circuit resource allocation
title_full_unstemmed	Programming mRNA decay to modulate synthetic circuit resource allocation
title_sort	programming mrna decay to modulate synthetic circuit resource allocation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c43786f35a0d4d08ac93c75c2b65d83c
work_keys_str_mv	AT opheliasventurelli programmingmrnadecaytomodulatesyntheticcircuitresourceallocation AT mikatei programmingmrnadecaytomodulatesyntheticcircuitresourceallocation AT stefanbauer programmingmrnadecaytomodulatesyntheticcircuitresourceallocation AT leannejadegchan programmingmrnadecaytomodulatesyntheticcircuitresourceallocation AT christopherjpetzold programmingmrnadecaytomodulatesyntheticcircuitresourceallocation AT adamparkin programmingmrnadecaytomodulatesyntheticcircuitresourceallocation
_version_	1718390018370699264

Programming mRNA decay to modulate synthetic circuit resource allocation

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