The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.

Human ether-à-go-go-related gene (hERG) K(+) channels have unusual gating kinetics. Characterised by slow activation/deactivation but rapid inactivation/recovery from inactivation, the unique gating kinetics underlie the central role hERG channels play in cardiac repolarisation. The slow activation...

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Autores principales: Chai Ann Ng, Matthew D Perry, Peter S Tan, Adam P Hill, Philip W Kuchel, Jamie I Vandenberg
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/c738808abc224046af0e7d81d27c1e04
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