A genetic cell context-dependent role for ZEB1 in lung cancer

ZEB1 is a driver of epithelial-to-mesenchymal transition that usually promotes lung cancer in the context of KRAS mutation. Here, the authors uncover a growth suppressive role for ZEB1 in EGFRmutant lung adenocarcinoma, thus elucidating the context dependent function of this protein.

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Autores principales:	Ting Zhang, Lixia Guo, Chad J. Creighton, Qiang Lu, Don L. Gibbons, Eunhee S. Yi, Bo Deng, Julian R. Molina, Zhifu Sun, Ping Yang, Yanan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8af796cf1bc4dac90587bd1750bc508
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c8af796cf1bc4dac90587bd1750bc5082021-12-02T14:39:48ZA genetic cell context-dependent role for ZEB1 in lung cancer10.1038/ncomms122312041-1723https://doaj.org/article/c8af796cf1bc4dac90587bd1750bc5082016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12231https://doaj.org/toc/2041-1723ZEB1 is a driver of epithelial-to-mesenchymal transition that usually promotes lung cancer in the context of KRAS mutation. Here, the authors uncover a growth suppressive role for ZEB1 in EGFRmutant lung adenocarcinoma, thus elucidating the context dependent function of this protein.Ting ZhangLixia GuoChad J. CreightonQiang LuDon L. GibbonsEunhee S. YiBo DengJulian R. MolinaZhifu SunPing YangYanan YangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting Zhang Lixia Guo Chad J. Creighton Qiang Lu Don L. Gibbons Eunhee S. Yi Bo Deng Julian R. Molina Zhifu Sun Ping Yang Yanan Yang A genetic cell context-dependent role for ZEB1 in lung cancer
description	ZEB1 is a driver of epithelial-to-mesenchymal transition that usually promotes lung cancer in the context of KRAS mutation. Here, the authors uncover a growth suppressive role for ZEB1 in EGFRmutant lung adenocarcinoma, thus elucidating the context dependent function of this protein.
format	article
author	Ting Zhang Lixia Guo Chad J. Creighton Qiang Lu Don L. Gibbons Eunhee S. Yi Bo Deng Julian R. Molina Zhifu Sun Ping Yang Yanan Yang
author_facet	Ting Zhang Lixia Guo Chad J. Creighton Qiang Lu Don L. Gibbons Eunhee S. Yi Bo Deng Julian R. Molina Zhifu Sun Ping Yang Yanan Yang
author_sort	Ting Zhang
title	A genetic cell context-dependent role for ZEB1 in lung cancer
title_short	A genetic cell context-dependent role for ZEB1 in lung cancer
title_full	A genetic cell context-dependent role for ZEB1 in lung cancer
title_fullStr	A genetic cell context-dependent role for ZEB1 in lung cancer
title_full_unstemmed	A genetic cell context-dependent role for ZEB1 in lung cancer
title_sort	genetic cell context-dependent role for zeb1 in lung cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c8af796cf1bc4dac90587bd1750bc508
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A genetic cell context-dependent role for ZEB1 in lung cancer

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