Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses
ABSTRACT Activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in antiviral responses to many DNA viruses. Sensing of cytosolic DNA by cGAS results in synthesis of the endogenous second messenger cGAMP that activates stimulator of interferon genes (STING) in infected cells. Crit...
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Auteurs principaux: | , , , , , , , , , , , , , , , |
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Format: | article |
Langue: | EN |
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American Society for Microbiology
2020
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Accès en ligne: | https://doaj.org/article/cbfc430aefe94522b1b1208699100db7 |
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