Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

ABSTRACT Activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in antiviral responses to many DNA viruses. Sensing of cytosolic DNA by cGAS results in synthesis of the endogenous second messenger cGAMP that activates stimulator of interferon genes (STING) in infected cells. Crit...

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Autores principales: Geneviève Pépin, Dominic De Nardo, Christina L. Rootes, Tomalika R. Ullah, Sumaiah S. Al-Asmari, Katherine R. Balka, Hong-Mei Li, Kylie M. Quinn, Fiona Moghaddas, Stephane Chappaz, Benjamin T. Kile, Eric F. Morand, Seth L. Masters, Cameron R. Stewart, Bryan R. G. Williams, Michael P. Gantier
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
connexins
STING
cGAMP
cGAS
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/cbfc430aefe94522b1b1208699100db7
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