Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

Patients with ovarium cancer frequently develop resistance to platinum chemotherapy and PARP inhibitors (PARPi). Here, the authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PARPi and platinum resistant ovarium cancer PDX models.

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Autores principales: Hyoung Kim, Haineng Xu, Erin George, Dorothy Hallberg, Sushil Kumar, Veena Jagannathan, Sergey Medvedev, Yasuto Kinose, Kyle Devins, Priyanka Verma, Kevin Ly, Yifan Wang, Roger A. Greenberg, Lauren Schwartz, Neil Johnson, Robert B. Scharpf, Gordon B. Mills, Rugang Zhang, Victor E. Velculescu, Eric J. Brown, Fiona Simpkins
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cc35bbdbfeb9477db7745da1954cd683
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spelling oai:doaj.org-article:cc35bbdbfeb9477db7745da1954cd6832021-12-02T16:17:57ZCombining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models10.1038/s41467-020-17127-22041-1723https://doaj.org/article/cc35bbdbfeb9477db7745da1954cd6832020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17127-2https://doaj.org/toc/2041-1723Patients with ovarium cancer frequently develop resistance to platinum chemotherapy and PARP inhibitors (PARPi). Here, the authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PARPi and platinum resistant ovarium cancer PDX models.Hyoung KimHaineng XuErin GeorgeDorothy HallbergSushil KumarVeena JagannathanSergey MedvedevYasuto KinoseKyle DevinsPriyanka VermaKevin LyYifan WangRoger A. GreenbergLauren SchwartzNeil JohnsonRobert B. ScharpfGordon B. MillsRugang ZhangVictor E. VelculescuEric J. BrownFiona SimpkinsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hyoung Kim
Haineng Xu
Erin George
Dorothy Hallberg
Sushil Kumar
Veena Jagannathan
Sergey Medvedev
Yasuto Kinose
Kyle Devins
Priyanka Verma
Kevin Ly
Yifan Wang
Roger A. Greenberg
Lauren Schwartz
Neil Johnson
Robert B. Scharpf
Gordon B. Mills
Rugang Zhang
Victor E. Velculescu
Eric J. Brown
Fiona Simpkins
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
description Patients with ovarium cancer frequently develop resistance to platinum chemotherapy and PARP inhibitors (PARPi). Here, the authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PARPi and platinum resistant ovarium cancer PDX models.
format article
author Hyoung Kim
Haineng Xu
Erin George
Dorothy Hallberg
Sushil Kumar
Veena Jagannathan
Sergey Medvedev
Yasuto Kinose
Kyle Devins
Priyanka Verma
Kevin Ly
Yifan Wang
Roger A. Greenberg
Lauren Schwartz
Neil Johnson
Robert B. Scharpf
Gordon B. Mills
Rugang Zhang
Victor E. Velculescu
Eric J. Brown
Fiona Simpkins
author_facet Hyoung Kim
Haineng Xu
Erin George
Dorothy Hallberg
Sushil Kumar
Veena Jagannathan
Sergey Medvedev
Yasuto Kinose
Kyle Devins
Priyanka Verma
Kevin Ly
Yifan Wang
Roger A. Greenberg
Lauren Schwartz
Neil Johnson
Robert B. Scharpf
Gordon B. Mills
Rugang Zhang
Victor E. Velculescu
Eric J. Brown
Fiona Simpkins
author_sort Hyoung Kim
title Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
title_short Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
title_full Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
title_fullStr Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
title_full_unstemmed Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
title_sort combining parp with atr inhibition overcomes parp inhibitor and platinum resistance in ovarian cancer models
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/cc35bbdbfeb9477db7745da1954cd683
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