The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

The cytoplasmic N-terminal domain of the human ether-a-go-go related gene (hERG) K+ channel is critical for the slow deactivation kinetics of the channel. However, the mechanism(s) by which the N-terminal domain regulates deactivation remains to be determined. Here we show that the solution NMR stru...

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Autores principales: Chai Ann Ng, Mark J Hunter, Matthew D Perry, Mehdi Mobli, Ying Ke, Philip W Kuchel, Glenn F King, Daniela Stock, Jamie I Vandenberg
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/cd58b092df8e48f98ebad7ea3a2f7210
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