A Mutation Upstream of the <italic toggle="yes">rplN-rpsD</italic> Ribosomal Operon Downregulates <named-content content-type="genus-species">Bordetella pertussis</named-content> Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages

A Mutation Upstream of the <italic toggle="yes">rplN-rpsD</italic> Ribosomal Operon Downregulates <named-content content-type="genus-species">Bordetella pertussis</named-content> Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages

ABSTRACT The BvgS/BvgA two-component system controls expression of ∼550 genes of Bordetella pertussis, of which, ∼245 virulence-related genes are positively regulated by the BvgS-phosphorylated transcriptional regulator protein BvgA (BvgA∼P). We found that a single G-to-T nucleotide transversion in...

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Autores principales: Jakub Novák, David Jurnečka, Irena Linhartová, Jana Holubová, Ondřej Staněk, Daniel Štipl, Ana Dienstbier, Branislav Večerek, Nayara Azevedo, Jan Provazník, Vladimír Beneš, Peter Šebo
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Bordetella pertussis
host-pathogen interactions
intracellular bacteria
macrophages
two-component regulatory systems
virulence regulation
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/cf6ec5a1115a47508d4d8820cec5b491
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