Machine learning classifies predictive kinematic features in a mouse model of neurodegeneration

Machine learning classifies predictive kinematic features in a mouse model of neurodegeneration

Abstract Motor deficits are observed in Alzheimer’s disease (AD) prior to the appearance of cognitive symptoms. To investigate the role of amyloid proteins in gait disturbances, we characterized locomotion in APP-overexpressing transgenic J20 mice. We used three-dimensional motion capture to charact...

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Main Authors: Ruyi Huang, Ali A. Nikooyan, Bo Xu, M. Selvan Joseph, Hamidreza Ghasemi Damavandi, Nathan von Trotha, Lilian Li, Ashok Bhattarai, Deeba Zadeh, Yeji Seo, Xingquan Liu, Patrick A. Truong, Edward H. Koo, J. C. Leiter, Daniel C. Lu
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/d361dba0120d4531af8263892c02a303
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https://doaj.org/article/d361dba0120d4531af8263892c02a303

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