KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

Mutant RAS family members occur in a wide range of tumour types, and there is a great interest in identifying isoform-specific inhibitors. Here, the authors characterise two designed ankyrin repeat proteins (DARPins) that specifically inhibit the KRAS isoform by binding to the region around the KRAS...

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Auteurs principaux: Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Science
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Accès en ligne:https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd
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https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd

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