Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for...

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Autores principales: Dimitri Papukashvili, Nino Rcheulishvili, Cong Liu, Fengfei Xie, Deependra Tyagi, Yunjiao He, Peng George Wang
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/e4a27aff5d79422abec24a1cddf5ced9
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spelling oai:doaj.org-article:e4a27aff5d79422abec24a1cddf5ced92021-11-25T17:09:48ZPerspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy10.3390/cells101129572073-4409https://doaj.org/article/e4a27aff5d79422abec24a1cddf5ced92021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2957https://doaj.org/toc/2073-4409Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.Dimitri PapukashviliNino RcheulishviliCong LiuFengfei XieDeependra TyagiYunjiao HePeng George WangMDPI AGarticlemiRNAAGADKK1Wnt/β-cateninhairBiology (General)QH301-705.5ENCells, Vol 10, Iss 2957, p 2957 (2021)
institution DOAJ
collection DOAJ
language EN
topic miRNA
AGA
DKK1
Wnt/β-catenin
hair
Biology (General)
QH301-705.5
spellingShingle miRNA
AGA
DKK1
Wnt/β-catenin
hair
Biology (General)
QH301-705.5
Dimitri Papukashvili
Nino Rcheulishvili
Cong Liu
Fengfei Xie
Deependra Tyagi
Yunjiao He
Peng George Wang
Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
description Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.
format article
author Dimitri Papukashvili
Nino Rcheulishvili
Cong Liu
Fengfei Xie
Deependra Tyagi
Yunjiao He
Peng George Wang
author_facet Dimitri Papukashvili
Nino Rcheulishvili
Cong Liu
Fengfei Xie
Deependra Tyagi
Yunjiao He
Peng George Wang
author_sort Dimitri Papukashvili
title Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
title_short Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
title_full Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
title_fullStr Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
title_full_unstemmed Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
title_sort perspectives on mirnas targeting dkk1 for developing hair regeneration therapy
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/e4a27aff5d79422abec24a1cddf5ced9
work_keys_str_mv AT dimitripapukashvili perspectivesonmirnastargetingdkk1fordevelopinghairregenerationtherapy
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AT yunjiaohe perspectivesonmirnastargetingdkk1fordevelopinghairregenerationtherapy
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