Effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass

Abstract A 71-day study was conducted to explore the effect of increasing dietary levels (0, 250, 500, 1000 mg kg feed−1; D0, D250, D500 and D1000, respectively) of a blend of microencapsulated organic acids (OA, specifically citric and sorbic acid) and nature identical compounds (NIC, specifically...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Serena Busti, Barbara Rossi, Enrico Volpe, Sara Ciulli, Andrea Piva, Federica D’Amico, Matteo Soverini, Marco Candela, Pier Paolo Gatta, Alessio Bonaldo, Ester Grilli, Luca Parma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e74c5c2ce09040618fc4f1e5c802d558
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e74c5c2ce09040618fc4f1e5c802d558
record_format	dspace
spelling	oai:doaj.org-article:e74c5c2ce09040618fc4f1e5c802d5582021-12-02T16:09:09ZEffects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass10.1038/s41598-020-78441-92045-2322https://doaj.org/article/e74c5c2ce09040618fc4f1e5c802d5582020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78441-9https://doaj.org/toc/2045-2322Abstract A 71-day study was conducted to explore the effect of increasing dietary levels (0, 250, 500, 1000 mg kg feed−1; D0, D250, D500 and D1000, respectively) of a blend of microencapsulated organic acids (OA, specifically citric and sorbic acid) and nature identical compounds (NIC, specifically thymol and vanillin), on growth, intestinal immune parameters and gut microbiota (GM) of European sea bass juveniles reared under normal and subsequently suboptimal environmental conditions (high temperature, 30.0 ± 0.4 °C and low oxygen, 4.6 ± 0.6 mg L−1). OA and NIC did not promote growth, feed utilisation and feed intake at the inclusion tested but induced a significantly upregulation of IL-8, IL-10 and TGFβ. GM analyzed by next-generation sequencing showed that OA and NIC were able to exert prebiotic properties stimulating the development of beneficial bacteria taxa such as Lactobacillus, Leuconostoc, and Bacillus sp. Picrust analyses displayed a significant potential functional reconfiguration of GM promoting a decrease in inflammation-promoting and homeostatic functions at increasing OA and NIC administration. For the first time on this species the exposure to suboptimal rearing conditions was able to modify GM structure reducing LAB and increasing Proteobacteria, findings which were consistent with the inflammatory process observed at mRNA level.Serena BustiBarbara RossiEnrico VolpeSara CiulliAndrea PivaFederica D’AmicoMatteo SoveriniMarco CandelaPier Paolo GattaAlessio BonaldoEster GrilliLuca ParmaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Serena Busti Barbara Rossi Enrico Volpe Sara Ciulli Andrea Piva Federica D’Amico Matteo Soverini Marco Candela Pier Paolo Gatta Alessio Bonaldo Ester Grilli Luca Parma Effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass
description	Abstract A 71-day study was conducted to explore the effect of increasing dietary levels (0, 250, 500, 1000 mg kg feed−1; D0, D250, D500 and D1000, respectively) of a blend of microencapsulated organic acids (OA, specifically citric and sorbic acid) and nature identical compounds (NIC, specifically thymol and vanillin), on growth, intestinal immune parameters and gut microbiota (GM) of European sea bass juveniles reared under normal and subsequently suboptimal environmental conditions (high temperature, 30.0 ± 0.4 °C and low oxygen, 4.6 ± 0.6 mg L−1). OA and NIC did not promote growth, feed utilisation and feed intake at the inclusion tested but induced a significantly upregulation of IL-8, IL-10 and TGFβ. GM analyzed by next-generation sequencing showed that OA and NIC were able to exert prebiotic properties stimulating the development of beneficial bacteria taxa such as Lactobacillus, Leuconostoc, and Bacillus sp. Picrust analyses displayed a significant potential functional reconfiguration of GM promoting a decrease in inflammation-promoting and homeostatic functions at increasing OA and NIC administration. For the first time on this species the exposure to suboptimal rearing conditions was able to modify GM structure reducing LAB and increasing Proteobacteria, findings which were consistent with the inflammatory process observed at mRNA level.
format	article
author	Serena Busti Barbara Rossi Enrico Volpe Sara Ciulli Andrea Piva Federica D’Amico Matteo Soverini Marco Candela Pier Paolo Gatta Alessio Bonaldo Ester Grilli Luca Parma
author_facet	Serena Busti Barbara Rossi Enrico Volpe Sara Ciulli Andrea Piva Federica D’Amico Matteo Soverini Marco Candela Pier Paolo Gatta Alessio Bonaldo Ester Grilli Luca Parma
author_sort	Serena Busti
title	Effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass
title_short	Effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass
title_full	Effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass
title_fullStr	Effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass
title_full_unstemmed	Effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass
title_sort	effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of european sea bass
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e74c5c2ce09040618fc4f1e5c802d558
work_keys_str_mv	AT serenabusti effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT barbararossi effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT enricovolpe effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT saraciulli effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT andreapiva effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT federicadamico effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT matteosoverini effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT marcocandela effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT pierpaologatta effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT alessiobonaldo effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT estergrilli effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass AT lucaparma effectsofdietaryorganicacidsandnatureidenticalcompoundsongrowthimmuneparametersandgutmicrobiotaofeuropeanseabass
_version_	1718384505259032576

Effects of dietary organic acids and nature identical compounds on growth, immune parameters and gut microbiota of European sea bass

Ejemplares similares