The complete structure of an activated open sodium channel
Voltage-gated sodium (Nav) channels are crucial for action potential initiation in excitable cells. Here the authors present the complete structure of prokaryotic NavMs in a fully open state, providing structural insight into the opening and closure of the channel's intracellular gate.
Saved in:
Main Authors: | Altin Sula, Jennifer Booker, Leo C. T. Ng, Claire E. Naylor, Paul G. DeCaen, B. A. Wallace |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/e9790fdf9aa34bac8509eea7e2e8e3c1 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Sodium channel activation underlies transfluthrin repellency in Aedes aegypti.
by: Felipe Andreazza, et al.
Published: (2021) -
Structure of the human sodium leak channel NALCN in complex with FAM155A
by: Jiongfang Xie, et al.
Published: (2020) -
Calcium-activated SK channels control firing regularity by modulating sodium channel availability in midbrain dopamine neurons
by: Rajeshwari Iyer, et al.
Published: (2017) -
Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex
by: Yunlu Kang, et al.
Published: (2020) -
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
by: Lyndsey L. Anderson, et al.
Published: (2017)