PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals

The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART s...

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Autores principales:	Rémi Fromentin, Sandrina DaFonseca, Cecilia T. Costiniuk, Mohamed El-Far, Francesco Andrea Procopio, Frederick M. Hecht, Rebecca Hoh, Steven G. Deeks, Daria J. Hazuda, Sharon R. Lewin, Jean-Pierre Routy, Rafick-Pierre Sékaly, Nicolas Chomont
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e996a4e085b845f09a6cdde3b15c9886
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spelling	oai:doaj.org-article:e996a4e085b845f09a6cdde3b15c98862021-12-02T17:01:52ZPD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals10.1038/s41467-019-08798-72041-1723https://doaj.org/article/e996a4e085b845f09a6cdde3b15c98862019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08798-7https://doaj.org/toc/2041-1723The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART suppressed individuals.Rémi FromentinSandrina DaFonsecaCecilia T. CostiniukMohamed El-FarFrancesco Andrea ProcopioFrederick M. HechtRebecca HohSteven G. DeeksDaria J. HazudaSharon R. LewinJean-Pierre RoutyRafick-Pierre SékalyNicolas ChomontNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rémi Fromentin Sandrina DaFonseca Cecilia T. Costiniuk Mohamed El-Far Francesco Andrea Procopio Frederick M. Hecht Rebecca Hoh Steven G. Deeks Daria J. Hazuda Sharon R. Lewin Jean-Pierre Routy Rafick-Pierre Sékaly Nicolas Chomont PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
description	The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART suppressed individuals.
format	article
author	Rémi Fromentin Sandrina DaFonseca Cecilia T. Costiniuk Mohamed El-Far Francesco Andrea Procopio Frederick M. Hecht Rebecca Hoh Steven G. Deeks Daria J. Hazuda Sharon R. Lewin Jean-Pierre Routy Rafick-Pierre Sékaly Nicolas Chomont
author_facet	Rémi Fromentin Sandrina DaFonseca Cecilia T. Costiniuk Mohamed El-Far Francesco Andrea Procopio Frederick M. Hecht Rebecca Hoh Steven G. Deeks Daria J. Hazuda Sharon R. Lewin Jean-Pierre Routy Rafick-Pierre Sékaly Nicolas Chomont
author_sort	Rémi Fromentin
title	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
title_short	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
title_full	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
title_fullStr	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
title_full_unstemmed	PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
title_sort	pd-1 blockade potentiates hiv latency reversal ex vivo in cd4+ t cells from art-suppressed individuals
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e996a4e085b845f09a6cdde3b15c9886
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PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals

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