A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region.

Guardado en:

Detalles Bibliográficos
Autores principales:	Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eb684694de314067aac5b53c9a7c86cd
record_format	dspace
spelling	oai:doaj.org-article:eb684694de314067aac5b53c9a7c86cd2021-12-02T16:04:17ZA missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction10.1038/s41467-020-16819-z2041-1723https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16819-zhttps://doaj.org/toc/2041-1723Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region.Joanne M. HildebrandMaria KauppiIan J. MajewskiZikou LiuAllison J. CoxSanae MiyakeEmma J. PetrieMichael A. SilkZhixiu LiMaria C. TanzerGabriela BrumattiSamuel N. YoungCathrine HallSarah E. GarnishJason CorbinMichael D. StutzLadina Di RagoPradnya GangatirkarEmma C. JosefssonKristin RigbyeHolly AndertonJames A. RickardAnne TripaydonisJulie SheridanThomas S. ScerriVictoria E. JacksonPeter E. CzabotarJian-Guo ZhangLeila VargheseCody C. AllisonMarc PellegriniGillian M. TannahillEsme C. HatchellTracy A. WillsonDina StockwellCarolyn A. de GraafJanelle CollingeAdrienne HiltonNatasha SilkeSukhdeep K. SpallDiep ChauVicki AthanasopoulosDonald MetcalfRonald M. LaxerAlexander G. BassukBenjamin W. DarbroMaria A. Fiatarone SinghNicole VlahovichDavid HughesMaria KozlovskaiaDavid B. AscherKlaus WarnatzNils VenhoffJens ThielChristine BibenStefan BlumJohn ReveilleMichael S. HildebrandCarola G. VinuesaPamela McCombeMatthew A. BrownBenjamin T. KileCatriona McLeanMelanie BahloSeth L. MastersHiroyasu NakanoPolly J. FergusonJames M. MurphyWarren S. AlexanderJohn SilkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanne M. Hildebrand Maria Kauppi Ian J. Majewski Zikou Liu Allison J. Cox Sanae Miyake Emma J. Petrie Michael A. Silk Zhixiu Li Maria C. Tanzer Gabriela Brumatti Samuel N. Young Cathrine Hall Sarah E. Garnish Jason Corbin Michael D. Stutz Ladina Di Rago Pradnya Gangatirkar Emma C. Josefsson Kristin Rigbye Holly Anderton James A. Rickard Anne Tripaydonis Julie Sheridan Thomas S. Scerri Victoria E. Jackson Peter E. Czabotar Jian-Guo Zhang Leila Varghese Cody C. Allison Marc Pellegrini Gillian M. Tannahill Esme C. Hatchell Tracy A. Willson Dina Stockwell Carolyn A. de Graaf Janelle Collinge Adrienne Hilton Natasha Silke Sukhdeep K. Spall Diep Chau Vicki Athanasopoulos Donald Metcalf Ronald M. Laxer Alexander G. Bassuk Benjamin W. Darbro Maria A. Fiatarone Singh Nicole Vlahovich David Hughes Maria Kozlovskaia David B. Ascher Klaus Warnatz Nils Venhoff Jens Thiel Christine Biben Stefan Blum John Reveille Michael S. Hildebrand Carola G. Vinuesa Pamela McCombe Matthew A. Brown Benjamin T. Kile Catriona McLean Melanie Bahlo Seth L. Masters Hiroyasu Nakano Polly J. Ferguson James M. Murphy Warren S. Alexander John Silke A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
description	Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region.
format	article
author	Joanne M. Hildebrand Maria Kauppi Ian J. Majewski Zikou Liu Allison J. Cox Sanae Miyake Emma J. Petrie Michael A. Silk Zhixiu Li Maria C. Tanzer Gabriela Brumatti Samuel N. Young Cathrine Hall Sarah E. Garnish Jason Corbin Michael D. Stutz Ladina Di Rago Pradnya Gangatirkar Emma C. Josefsson Kristin Rigbye Holly Anderton James A. Rickard Anne Tripaydonis Julie Sheridan Thomas S. Scerri Victoria E. Jackson Peter E. Czabotar Jian-Guo Zhang Leila Varghese Cody C. Allison Marc Pellegrini Gillian M. Tannahill Esme C. Hatchell Tracy A. Willson Dina Stockwell Carolyn A. de Graaf Janelle Collinge Adrienne Hilton Natasha Silke Sukhdeep K. Spall Diep Chau Vicki Athanasopoulos Donald Metcalf Ronald M. Laxer Alexander G. Bassuk Benjamin W. Darbro Maria A. Fiatarone Singh Nicole Vlahovich David Hughes Maria Kozlovskaia David B. Ascher Klaus Warnatz Nils Venhoff Jens Thiel Christine Biben Stefan Blum John Reveille Michael S. Hildebrand Carola G. Vinuesa Pamela McCombe Matthew A. Brown Benjamin T. Kile Catriona McLean Melanie Bahlo Seth L. Masters Hiroyasu Nakano Polly J. Ferguson James M. Murphy Warren S. Alexander John Silke
author_facet	Joanne M. Hildebrand Maria Kauppi Ian J. Majewski Zikou Liu Allison J. Cox Sanae Miyake Emma J. Petrie Michael A. Silk Zhixiu Li Maria C. Tanzer Gabriela Brumatti Samuel N. Young Cathrine Hall Sarah E. Garnish Jason Corbin Michael D. Stutz Ladina Di Rago Pradnya Gangatirkar Emma C. Josefsson Kristin Rigbye Holly Anderton James A. Rickard Anne Tripaydonis Julie Sheridan Thomas S. Scerri Victoria E. Jackson Peter E. Czabotar Jian-Guo Zhang Leila Varghese Cody C. Allison Marc Pellegrini Gillian M. Tannahill Esme C. Hatchell Tracy A. Willson Dina Stockwell Carolyn A. de Graaf Janelle Collinge Adrienne Hilton Natasha Silke Sukhdeep K. Spall Diep Chau Vicki Athanasopoulos Donald Metcalf Ronald M. Laxer Alexander G. Bassuk Benjamin W. Darbro Maria A. Fiatarone Singh Nicole Vlahovich David Hughes Maria Kozlovskaia David B. Ascher Klaus Warnatz Nils Venhoff Jens Thiel Christine Biben Stefan Blum John Reveille Michael S. Hildebrand Carola G. Vinuesa Pamela McCombe Matthew A. Brown Benjamin T. Kile Catriona McLean Melanie Bahlo Seth L. Masters Hiroyasu Nakano Polly J. Ferguson James M. Murphy Warren S. Alexander John Silke
author_sort	Joanne M. Hildebrand
title	A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
title_short	A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
title_full	A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
title_fullStr	A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
title_full_unstemmed	A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
title_sort	missense mutation in the mlkl brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd
work_keys_str_mv	AT joannemhildebrand amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT mariakauppi amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT ianjmajewski amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT zikouliu amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT allisonjcox amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT sanaemiyake amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT emmajpetrie amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT michaelasilk amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT zhixiuli amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT mariactanzer amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT gabrielabrumatti amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT samuelnyoung amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT cathrinehall amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT sarahegarnish amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jasoncorbin amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT michaeldstutz amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT ladinadirago amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT pradnyagangatirkar amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT emmacjosefsson amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT kristinrigbye amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT hollyanderton amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jamesarickard amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT annetripaydonis amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT juliesheridan amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT thomassscerri amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT victoriaejackson amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT petereczabotar amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jianguozhang amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT leilavarghese amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT codycallison amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT marcpellegrini amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT gillianmtannahill amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT esmechatchell amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT tracyawillson amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT dinastockwell amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT carolynadegraaf amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT janellecollinge amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT adriennehilton amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT natashasilke amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT sukhdeepkspall amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT diepchau amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT vickiathanasopoulos amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT donaldmetcalf amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT ronaldmlaxer amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT alexandergbassuk amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT benjaminwdarbro amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT mariaafiataronesingh amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT nicolevlahovich amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT davidhughes amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT mariakozlovskaia amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT davidbascher amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT klauswarnatz amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT nilsvenhoff amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jensthiel amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT christinebiben amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT stefanblum amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT johnreveille amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT michaelshildebrand amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT carolagvinuesa amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT pamelamccombe amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT matthewabrown amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT benjamintkile amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT catrionamclean amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT melaniebahlo amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT sethlmasters amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT hiroyasunakano amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT pollyjferguson amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jamesmmurphy amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT warrensalexander amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT johnsilke amissensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT joannemhildebrand missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT mariakauppi missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT ianjmajewski missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT zikouliu missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT allisonjcox missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT sanaemiyake missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT emmajpetrie missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT michaelasilk missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT zhixiuli missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT mariactanzer missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT gabrielabrumatti missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT samuelnyoung missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT cathrinehall missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT sarahegarnish missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jasoncorbin missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT michaeldstutz missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT ladinadirago missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT pradnyagangatirkar missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT emmacjosefsson missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT kristinrigbye missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT hollyanderton missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jamesarickard missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT annetripaydonis missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT juliesheridan missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT thomassscerri missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT victoriaejackson missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT petereczabotar missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jianguozhang missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT leilavarghese missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT codycallison missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT marcpellegrini missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT gillianmtannahill missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT esmechatchell missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT tracyawillson missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT dinastockwell missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT carolynadegraaf missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT janellecollinge missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT adriennehilton missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT natashasilke missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT sukhdeepkspall missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT diepchau missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT vickiathanasopoulos missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT donaldmetcalf missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT ronaldmlaxer missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT alexandergbassuk missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT benjaminwdarbro missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT mariaafiataronesingh missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT nicolevlahovich missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT davidhughes missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT mariakozlovskaia missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT davidbascher missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT klauswarnatz missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT nilsvenhoff missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jensthiel missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT christinebiben missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT stefanblum missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT johnreveille missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT michaelshildebrand missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT carolagvinuesa missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT pamelamccombe missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT matthewabrown missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT benjamintkile missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT catrionamclean missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT melaniebahlo missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT sethlmasters missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT hiroyasunakano missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT pollyjferguson missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT jamesmmurphy missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT warrensalexander missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction AT johnsilke missensemutationinthemlklbraceregionpromoteslethalneonatalinflammationandhematopoieticdysfunction
_version_	1718385303813619712

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Ejemplares similares