Dynamically-driven inactivation of the catalytic machinery of the SARS 3C-like protease by the N214A mutation on the extra domain.

Despite utilizing the same chymotrypsin fold to host the catalytic machinery, coronavirus 3C-like proteases (3CLpro) noticeably differ from picornavirus 3C proteases in acquiring an extra helical domain in evolution. Previously, the extra domain was demonstrated to regulate the catalysis of the SARS...

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Autores principales: Jiahai Shi, Nanyu Han, Liangzhong Lim, Shixiong Lua, J Sivaraman, Lushan Wang, Yuguang Mu, Jianxing Song
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/f026559c58b04c01ab9e1e26e0f6eea6
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