AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications

Focal copy number amplifications (fCNAs), which drive cancer pathogenicity, arise by a number of mechanisms and can be challenging to call. Here the authors present AmpliconReconstructor for precise and scalable fCNA reconstruction using optical mapping and next-generation sequencing data.

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Autores principales:	Jens Luebeck, Ceyda Coruh, Siavash R. Dehkordi, Joshua T. Lange, Kristen M. Turner, Viraj Deshpande, Dave A. Pai, Chao Zhang, Utkrisht Rajkumar, Julie A. Law, Paul S. Mischel, Vineet Bafna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f072105319bb4cc08d37a2a5027abc98
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spelling	oai:doaj.org-article:f072105319bb4cc08d37a2a5027abc982021-12-02T19:04:01ZAmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications10.1038/s41467-020-18099-z2041-1723https://doaj.org/article/f072105319bb4cc08d37a2a5027abc982020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18099-zhttps://doaj.org/toc/2041-1723Focal copy number amplifications (fCNAs), which drive cancer pathogenicity, arise by a number of mechanisms and can be challenging to call. Here the authors present AmpliconReconstructor for precise and scalable fCNA reconstruction using optical mapping and next-generation sequencing data.Jens LuebeckCeyda CoruhSiavash R. DehkordiJoshua T. LangeKristen M. TurnerViraj DeshpandeDave A. PaiChao ZhangUtkrisht RajkumarJulie A. LawPaul S. MischelVineet BafnaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jens Luebeck Ceyda Coruh Siavash R. Dehkordi Joshua T. Lange Kristen M. Turner Viraj Deshpande Dave A. Pai Chao Zhang Utkrisht Rajkumar Julie A. Law Paul S. Mischel Vineet Bafna AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
description	Focal copy number amplifications (fCNAs), which drive cancer pathogenicity, arise by a number of mechanisms and can be challenging to call. Here the authors present AmpliconReconstructor for precise and scalable fCNA reconstruction using optical mapping and next-generation sequencing data.
format	article
author	Jens Luebeck Ceyda Coruh Siavash R. Dehkordi Joshua T. Lange Kristen M. Turner Viraj Deshpande Dave A. Pai Chao Zhang Utkrisht Rajkumar Julie A. Law Paul S. Mischel Vineet Bafna
author_facet	Jens Luebeck Ceyda Coruh Siavash R. Dehkordi Joshua T. Lange Kristen M. Turner Viraj Deshpande Dave A. Pai Chao Zhang Utkrisht Rajkumar Julie A. Law Paul S. Mischel Vineet Bafna
author_sort	Jens Luebeck
title	AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
title_short	AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
title_full	AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
title_fullStr	AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
title_full_unstemmed	AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
title_sort	ampliconreconstructor integrates ngs and optical mapping to resolve the complex structures of focal amplifications
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f072105319bb4cc08d37a2a5027abc98
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AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications

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