Functional rotation of the transporter AcrB: insights into drug extrusion from simulations.

The tripartite complex AcrAB-TolC is the major efflux system in Escherichia coli. It extrudes a wide spectrum of noxious compounds out of the bacterium, including many antibiotics. Its active part, the homotrimeric transporter AcrB, is responsible for the selective binding of substrates and energy t...

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Bibliographic Details
Main Authors: Robert Schulz, Attilio V Vargiu, Francesca Collu, Ulrich Kleinekathöfer, Paolo Ruggerone
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
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Online Access:https://doaj.org/article/f09fe10093e74a379063b2e3610e2371
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