A novel ex vivo isolation and expansion procedure for chimeric antigen receptor engrafted human T cells.

A novel ex vivo isolation and expansion procedure for chimeric antigen receptor engrafted human T cells.

Genetically engineered T lymphocytes are a promising option for cancer therapy. Prior to adoptive transfer they have to be expanded in vitro to reach therapeutically sufficient numbers. So far, no universal method exists for selective in vitro expansion of engineered T lymphocytes. In order to overc...

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Bibliographic Details
Main Authors: Marc Cartellieri, Stefanie Koristka, Claudia Arndt, Anja Feldmann, Slava Stamova, Malte von Bonin, Katrin Töpfer, Thomas Krüger, Mathias Geib, Irene Michalk, Achim Temme, Martin Bornhäuser, Dirk Lindemann, Gerhard Ehninger, Michael P Bachmann
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f142152a744f4caf9d7376f363460801
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https://doaj.org/article/f142152a744f4caf9d7376f363460801

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