Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins

Protein repeats may be considered a paradox, being evolutionarily conserved yet also hotspots of protein evolution associated with innovation. Here, the authors use a novel method to show that new repeats undergo rapid divergence within species, but are then fixed and conserved between species.

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Auteurs principaux: Erez Persi, Yuri I. Wolf, Eugene V Koonin
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/f21094ba5e1f44e5a9b02459431657e9
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spelling oai:doaj.org-article:f21094ba5e1f44e5a9b02459431657e92021-12-02T17:31:20ZPositive and strongly relaxed purifying selection drive the evolution of repeats in proteins10.1038/ncomms135702041-1723https://doaj.org/article/f21094ba5e1f44e5a9b02459431657e92016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13570https://doaj.org/toc/2041-1723Protein repeats may be considered a paradox, being evolutionarily conserved yet also hotspots of protein evolution associated with innovation. Here, the authors use a novel method to show that new repeats undergo rapid divergence within species, but are then fixed and conserved between species.Erez PersiYuri I. WolfEugene V KooninNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Erez Persi
Yuri I. Wolf
Eugene V Koonin
Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins
description Protein repeats may be considered a paradox, being evolutionarily conserved yet also hotspots of protein evolution associated with innovation. Here, the authors use a novel method to show that new repeats undergo rapid divergence within species, but are then fixed and conserved between species.
format article
author Erez Persi
Yuri I. Wolf
Eugene V Koonin
author_facet Erez Persi
Yuri I. Wolf
Eugene V Koonin
author_sort Erez Persi
title Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins
title_short Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins
title_full Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins
title_fullStr Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins
title_full_unstemmed Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins
title_sort positive and strongly relaxed purifying selection drive the evolution of repeats in proteins
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/f21094ba5e1f44e5a9b02459431657e9
work_keys_str_mv AT erezpersi positiveandstronglyrelaxedpurifyingselectiondrivetheevolutionofrepeatsinproteins
AT yuriiwolf positiveandstronglyrelaxedpurifyingselectiondrivetheevolutionofrepeatsinproteins
AT eugenevkoonin positiveandstronglyrelaxedpurifyingselectiondrivetheevolutionofrepeatsinproteins
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