PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the mechanism of action.

Saved in:
Bibliographic Details
Main Authors: Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/f4adc148d44f418d9df058242e7f3bd6
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/f4adc148d44f418d9df058242e7f3bd6

Similar Items