Dissection of the amyloid formation pathway in AL amyloidosis

AL amyloidosis is caused by the accumulation of overproduced light chain (LC) fragments as fibrils in patient organs and it is the most prevalent systemic amyloidosis. Here, the authors combine biochemical and biophysical experiments to characterise the lag phase of a patient-derived truncated LC an...

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Autores principales: Pamina Kazman, Ramona M. Absmeier, Harald Engelhardt, Johannes Buchner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f5aabe6c6d2e492680e49c828972990f
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