Dissection of the amyloid formation pathway in AL amyloidosis

AL amyloidosis is caused by the accumulation of overproduced light chain (LC) fragments as fibrils in patient organs and it is the most prevalent systemic amyloidosis. Here, the authors combine biochemical and biophysical experiments to characterise the lag phase of a patient-derived truncated LC an...

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Autores principales:	Pamina Kazman, Ramona M. Absmeier, Harald Engelhardt, Johannes Buchner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f5aabe6c6d2e492680e49c828972990f
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spelling	oai:doaj.org-article:f5aabe6c6d2e492680e49c828972990f2021-11-14T12:34:06ZDissection of the amyloid formation pathway in AL amyloidosis10.1038/s41467-021-26845-02041-1723https://doaj.org/article/f5aabe6c6d2e492680e49c828972990f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26845-0https://doaj.org/toc/2041-1723AL amyloidosis is caused by the accumulation of overproduced light chain (LC) fragments as fibrils in patient organs and it is the most prevalent systemic amyloidosis. Here, the authors combine biochemical and biophysical experiments to characterise the lag phase of a patient-derived truncated LC and they identify structural transitions that precede fibril formation.Pamina KazmanRamona M. AbsmeierHarald EngelhardtJohannes BuchnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pamina Kazman Ramona M. Absmeier Harald Engelhardt Johannes Buchner Dissection of the amyloid formation pathway in AL amyloidosis
description	AL amyloidosis is caused by the accumulation of overproduced light chain (LC) fragments as fibrils in patient organs and it is the most prevalent systemic amyloidosis. Here, the authors combine biochemical and biophysical experiments to characterise the lag phase of a patient-derived truncated LC and they identify structural transitions that precede fibril formation.
format	article
author	Pamina Kazman Ramona M. Absmeier Harald Engelhardt Johannes Buchner
author_facet	Pamina Kazman Ramona M. Absmeier Harald Engelhardt Johannes Buchner
author_sort	Pamina Kazman
title	Dissection of the amyloid formation pathway in AL amyloidosis
title_short	Dissection of the amyloid formation pathway in AL amyloidosis
title_full	Dissection of the amyloid formation pathway in AL amyloidosis
title_fullStr	Dissection of the amyloid formation pathway in AL amyloidosis
title_full_unstemmed	Dissection of the amyloid formation pathway in AL amyloidosis
title_sort	dissection of the amyloid formation pathway in al amyloidosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f5aabe6c6d2e492680e49c828972990f
work_keys_str_mv	AT paminakazman dissectionoftheamyloidformationpathwayinalamyloidosis AT ramonamabsmeier dissectionoftheamyloidformationpathwayinalamyloidosis AT haraldengelhardt dissectionoftheamyloidformationpathwayinalamyloidosis AT johannesbuchner dissectionoftheamyloidformationpathwayinalamyloidosis
_version_	1718429204306984960

Dissection of the amyloid formation pathway in AL amyloidosis

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