Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4

Selenoproteins are a small family of proteins containing the trace element selenium in form of the rare amino acid selenocysteine (Sec), which is decoded by the UGA codon. In humans, a number of pathogenic variants in genes encoding distinct selenoproteins or selenoprotein biosynthesis factors have...

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Autores principales: Noelia Fradejas-Villar, Wenchao Zhao, Uschi Reuter, Michael Doengi, Irina Ingold, Simon Bohleber, Marcus Conrad, Ulrich Schweizer
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/f6302178548c423e8a2aad1b6790908b
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