CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Cdk12 is primarily involved in the regulation of DNA damage response (DDR) gene transcription as well as mRNA processing. Here, the authors demonstrate that CDK12 suppresses intronic polyadenylation, and that inhibition of this kinase primarily affects the expression of long genes with higher number...

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Autores principales:	Malgorzata Krajewska, Ruben Dries, Andrew V. Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L. Greenleaf, Guo-Cheng Yuan, Nathanael S. Gray, Richard A. Young, Matthias Geyer, Scott A. Gerber, Rani E. George
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fedbb8762827499baca37a345fd99c5e
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spelling	oai:doaj.org-article:fedbb8762827499baca37a345fd99c5e2021-12-02T17:01:45ZCDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation10.1038/s41467-019-09703-y2041-1723https://doaj.org/article/fedbb8762827499baca37a345fd99c5e2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09703-yhttps://doaj.org/toc/2041-1723Cdk12 is primarily involved in the regulation of DNA damage response (DDR) gene transcription as well as mRNA processing. Here, the authors demonstrate that CDK12 suppresses intronic polyadenylation, and that inhibition of this kinase primarily affects the expression of long genes with higher numbers of polyA sites, features common to many DDR genes.Malgorzata KrajewskaRuben DriesAndrew V. GrassettiSofia DustYang GaoHao HuangBandana SharmaDaniel S. DayNicholas KwiatkowskiMonica PomavilleOliver DoddEdmond ChipumuroTinghu ZhangArno L. GreenleafGuo-Cheng YuanNathanael S. GrayRichard A. YoungMatthias GeyerScott A. GerberRani E. GeorgeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Malgorzata Krajewska Ruben Dries Andrew V. Grassetti Sofia Dust Yang Gao Hao Huang Bandana Sharma Daniel S. Day Nicholas Kwiatkowski Monica Pomaville Oliver Dodd Edmond Chipumuro Tinghu Zhang Arno L. Greenleaf Guo-Cheng Yuan Nathanael S. Gray Richard A. Young Matthias Geyer Scott A. Gerber Rani E. George CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
description	Cdk12 is primarily involved in the regulation of DNA damage response (DDR) gene transcription as well as mRNA processing. Here, the authors demonstrate that CDK12 suppresses intronic polyadenylation, and that inhibition of this kinase primarily affects the expression of long genes with higher numbers of polyA sites, features common to many DDR genes.
format	article
author	Malgorzata Krajewska Ruben Dries Andrew V. Grassetti Sofia Dust Yang Gao Hao Huang Bandana Sharma Daniel S. Day Nicholas Kwiatkowski Monica Pomaville Oliver Dodd Edmond Chipumuro Tinghu Zhang Arno L. Greenleaf Guo-Cheng Yuan Nathanael S. Gray Richard A. Young Matthias Geyer Scott A. Gerber Rani E. George
author_facet	Malgorzata Krajewska Ruben Dries Andrew V. Grassetti Sofia Dust Yang Gao Hao Huang Bandana Sharma Daniel S. Day Nicholas Kwiatkowski Monica Pomaville Oliver Dodd Edmond Chipumuro Tinghu Zhang Arno L. Greenleaf Guo-Cheng Yuan Nathanael S. Gray Richard A. Young Matthias Geyer Scott A. Gerber Rani E. George
author_sort	Malgorzata Krajewska
title	CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
title_short	CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
title_full	CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
title_fullStr	CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
title_full_unstemmed	CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
title_sort	cdk12 loss in cancer cells affects dna damage response genes through premature cleavage and polyadenylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fedbb8762827499baca37a345fd99c5e
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CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

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