Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

Large RNAs and ribonucleoprotein complexes have shown potential as novel therapeutic agents, but their targeted delivery to cells is still challenging. Here the authors present a modular aptamer nanostructure for intracellular delivery of RNAs up to 250 nucleotides to cancer cells.

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Autores principales: David Porciani, Leah N. Cardwell, Kwaku D. Tawiah, Khalid K. Alam, Margaret J. Lange, Mark A. Daniels, Donald H. Burke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ffee912c372c4f2bb7d08733a0e28329
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spelling oai:doaj.org-article:ffee912c372c4f2bb7d08733a0e283292021-12-02T17:32:02ZModular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines10.1038/s41467-018-04691-x2041-1723https://doaj.org/article/ffee912c372c4f2bb7d08733a0e283292018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04691-xhttps://doaj.org/toc/2041-1723Large RNAs and ribonucleoprotein complexes have shown potential as novel therapeutic agents, but their targeted delivery to cells is still challenging. Here the authors present a modular aptamer nanostructure for intracellular delivery of RNAs up to 250 nucleotides to cancer cells.David PorcianiLeah N. CardwellKwaku D. TawiahKhalid K. AlamMargaret J. LangeMark A. DanielsDonald H. BurkeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
David Porciani
Leah N. Cardwell
Kwaku D. Tawiah
Khalid K. Alam
Margaret J. Lange
Mark A. Daniels
Donald H. Burke
Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
description Large RNAs and ribonucleoprotein complexes have shown potential as novel therapeutic agents, but their targeted delivery to cells is still challenging. Here the authors present a modular aptamer nanostructure for intracellular delivery of RNAs up to 250 nucleotides to cancer cells.
format article
author David Porciani
Leah N. Cardwell
Kwaku D. Tawiah
Khalid K. Alam
Margaret J. Lange
Mark A. Daniels
Donald H. Burke
author_facet David Porciani
Leah N. Cardwell
Kwaku D. Tawiah
Khalid K. Alam
Margaret J. Lange
Mark A. Daniels
Donald H. Burke
author_sort David Porciani
title Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_short Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_full Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_fullStr Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_full_unstemmed Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_sort modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional rnas in cancer cell lines
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ffee912c372c4f2bb7d08733a0e28329
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