Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

Large RNAs and ribonucleoprotein complexes have shown potential as novel therapeutic agents, but their targeted delivery to cells is still challenging. Here the authors present a modular aptamer nanostructure for intracellular delivery of RNAs up to 250 nucleotides to cancer cells.

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Auteurs principaux:	David Porciani, Leah N. Cardwell, Kwaku D. Tawiah, Khalid K. Alam, Margaret J. Lange, Mark A. Daniels, Donald H. Burke
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ffee912c372c4f2bb7d08733a0e28329
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spelling	oai:doaj.org-article:ffee912c372c4f2bb7d08733a0e283292021-12-02T17:32:02ZModular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines10.1038/s41467-018-04691-x2041-1723https://doaj.org/article/ffee912c372c4f2bb7d08733a0e283292018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04691-xhttps://doaj.org/toc/2041-1723Large RNAs and ribonucleoprotein complexes have shown potential as novel therapeutic agents, but their targeted delivery to cells is still challenging. Here the authors present a modular aptamer nanostructure for intracellular delivery of RNAs up to 250 nucleotides to cancer cells.David PorcianiLeah N. CardwellKwaku D. TawiahKhalid K. AlamMargaret J. LangeMark A. DanielsDonald H. BurkeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Porciani Leah N. Cardwell Kwaku D. Tawiah Khalid K. Alam Margaret J. Lange Mark A. Daniels Donald H. Burke Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
description	Large RNAs and ribonucleoprotein complexes have shown potential as novel therapeutic agents, but their targeted delivery to cells is still challenging. Here the authors present a modular aptamer nanostructure for intracellular delivery of RNAs up to 250 nucleotides to cancer cells.
format	article
author	David Porciani Leah N. Cardwell Kwaku D. Tawiah Khalid K. Alam Margaret J. Lange Mark A. Daniels Donald H. Burke
author_facet	David Porciani Leah N. Cardwell Kwaku D. Tawiah Khalid K. Alam Margaret J. Lange Mark A. Daniels Donald H. Burke
author_sort	David Porciani
title	Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_short	Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_full	Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_fullStr	Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_full_unstemmed	Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines
title_sort	modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional rnas in cancer cell lines
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ffee912c372c4f2bb7d08733a0e28329
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Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

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