Folatos y vitamina B12 en la salud humana

During the past decade the role of folate and vitamin B12 in human nutrition have been under constant re-examination. Basic knowledge on the metabolism and interactions between these essential nutrients has expanded and multiple complexities have been unraveled. These micronutrients have shared func...

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Autores principales:	Brito,Alex, Hertrampf,Eva, Olivares,Manuel, Gaitán,Diego, Sánchez,Hugo, Allen,Lindsay H, Uauy,Ricardo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2012
Materias:	Folic acid Micronutrients Vitamin B12
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001100014
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spelling	oai:scielo:S0034-988720120011000142013-05-07Folatos y vitamina B12 en la salud humanaBrito,AlexHertrampf,EvaOlivares,ManuelGaitán,DiegoSánchez,HugoAllen,Lindsay HUauy,Ricardo Folic acid Micronutrients Vitamin B12 During the past decade the role of folate and vitamin B12 in human nutrition have been under constant re-examination. Basic knowledge on the metabolism and interactions between these essential nutrients has expanded and multiple complexities have been unraveled. These micronutrients have shared functions and intertwined metabolic pathways that define the size of the "methyl donor" pool utilized in multiple metabolic pathways; these include DNA methylation and synthesis of nucleic acids. In Chile, folate deficiency is virtually nonexistent, while vitamin B12 deficiency affects approximately 8.5-51% depending on the cut-off value used to define deficiency. Folate is found naturally mainly in vegetables or added as folic acid to staple foods. Vitamin B12 in its natural form is present only in foods of animal origin, which is why deficit is more common among strict vegetarians and populations with a low intake of animal foods. Poorfolate status in vulnerable women of childbearing age increases the risk of neural tube birth defects, so the critical time for the contribution of folic acid is several months before conception since neural tube closure occurs during the first weeks of life. The absorption of vitamin B12 from food is lower in older adults, who are considered to have higher risk of gastric mucosa atrophy, altered production of intrinsic factor and acid secretion. Deficiency of these vitamins is associated with hematological disorders. Vitamin B12 deficiency can also induce clinical and sub-clinical neurological and of other disorders. The purpose of this review is to provide an update on recent advances in the basic and applied knowledge of these vitamins relative to human health.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.140 n.11 20122012-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001100014es10.4067/S0034-98872012001100014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Folic acid Micronutrients Vitamin B12
spellingShingle	Folic acid Micronutrients Vitamin B12 Brito,Alex Hertrampf,Eva Olivares,Manuel Gaitán,Diego Sánchez,Hugo Allen,Lindsay H Uauy,Ricardo Folatos y vitamina B12 en la salud humana
description	During the past decade the role of folate and vitamin B12 in human nutrition have been under constant re-examination. Basic knowledge on the metabolism and interactions between these essential nutrients has expanded and multiple complexities have been unraveled. These micronutrients have shared functions and intertwined metabolic pathways that define the size of the "methyl donor" pool utilized in multiple metabolic pathways; these include DNA methylation and synthesis of nucleic acids. In Chile, folate deficiency is virtually nonexistent, while vitamin B12 deficiency affects approximately 8.5-51% depending on the cut-off value used to define deficiency. Folate is found naturally mainly in vegetables or added as folic acid to staple foods. Vitamin B12 in its natural form is present only in foods of animal origin, which is why deficit is more common among strict vegetarians and populations with a low intake of animal foods. Poorfolate status in vulnerable women of childbearing age increases the risk of neural tube birth defects, so the critical time for the contribution of folic acid is several months before conception since neural tube closure occurs during the first weeks of life. The absorption of vitamin B12 from food is lower in older adults, who are considered to have higher risk of gastric mucosa atrophy, altered production of intrinsic factor and acid secretion. Deficiency of these vitamins is associated with hematological disorders. Vitamin B12 deficiency can also induce clinical and sub-clinical neurological and of other disorders. The purpose of this review is to provide an update on recent advances in the basic and applied knowledge of these vitamins relative to human health.
author	Brito,Alex Hertrampf,Eva Olivares,Manuel Gaitán,Diego Sánchez,Hugo Allen,Lindsay H Uauy,Ricardo
author_facet	Brito,Alex Hertrampf,Eva Olivares,Manuel Gaitán,Diego Sánchez,Hugo Allen,Lindsay H Uauy,Ricardo
author_sort	Brito,Alex
title	Folatos y vitamina B12 en la salud humana
title_short	Folatos y vitamina B12 en la salud humana
title_full	Folatos y vitamina B12 en la salud humana
title_fullStr	Folatos y vitamina B12 en la salud humana
title_full_unstemmed	Folatos y vitamina B12 en la salud humana
title_sort	folatos y vitamina b12 en la salud humana
publisher	Sociedad Médica de Santiago
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012001100014
work_keys_str_mv	AT britoalex folatosyvitaminab12enlasaludhumana AT hertrampfeva folatosyvitaminab12enlasaludhumana AT olivaresmanuel folatosyvitaminab12enlasaludhumana AT gaitandiego folatosyvitaminab12enlasaludhumana AT sanchezhugo folatosyvitaminab12enlasaludhumana AT allenlindsayh folatosyvitaminab12enlasaludhumana AT uauyricardo folatosyvitaminab12enlasaludhumana
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Folatos y vitamina B12 en la salud humana

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