CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

por Malgorzata Krajewska, Ruben Dries, Andrew V. Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L. Greenleaf, Guo-Cheng Yuan, Nathanael S. Gray, Richard A. Young, Matthias Geyer, Scott A. Gerber, Rani E. George
Publicado 2019

Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion

por J. Konen, E. Summerbell, B. Dwivedi, K. Galior, Y. Hou, L. Rusnak, A. Chen, J. Saltz, W. Zhou, L. H. Boise, P. Vertino, L. Cooper, K. Salaita, J. Kowalski, A. I. Marcus
Publicado 2017

c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

por Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Publicado 2019

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

por Lisanne F. van Dessel, Job van Riet, Minke Smits, Yanyun Zhu, Paul Hamberg, Michiel S. van der Heijden, Andries M. Bergman, Inge M. van Oort, Ronald de Wit, Emile E. Voest, Neeltje Steeghs, Takafumi N. Yamaguchi, Julie Livingstone, Paul C. Boutros, John W. M. Martens, Stefan Sleijfer, Edwin Cuppen, Wilbert Zwart, Harmen J. G. van de Werken, Niven Mehra, Martijn P. Lolkema
Publicado 2019

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

por Ankur Chakravarthy, Lubaba Khan, Nathan Peter Bensler, Pinaki Bose, Daniel D. De Carvalho
Publicado 2018

Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells

por Heping Cao, Kandan Sethumadhavan, Fangping Cao, Thomas T. Y. Wang
Publicado 2021

Predictors for development of denosumab-induced hypocalcaemia in cancer patients with bone metastases determined by ordered logistic regression analysis

por Yuko Kanbayashi, Koichi Sakaguchi, Fumiya Hongo, Takeshi Ishikawa, Yusuke Tabuchi, Osamu Ukimura, Koichi Takayama, Tetsuya Taguchi
Publicado 2021

Prognostic significance of CD8+ T-cells density in stage III colorectal cancer depends on SDF-1 expression

por Alexandros Lalos, Ali Tülek, Nadia Tosti, Robert Mechera, Alexander Wilhelm, Savas Soysal, Silvio Daester, Venkatesh Kancherla, Benjamin Weixler, Giulio C. Spagnoli, Serenella Eppenberger-Castori, Luigi Terracciano, Salvatore Piscuoglio, Markus von Flüe, Alberto Posabella, Raoul A. Droeser
Publicado 2021

Enhanced Antitumor Efficacy of Macrophage-Mediated Egg Yolk Lipid-Derived Delivery System Against Breast Cancer

por Lv Y, Jun Y, Tang Z, Li X, Tao M, Zhang Z, Liu L, Sun S, Wang Q, Luo C, Zhang L
Publicado 2020

Identification and validation of a miRNA-based prognostic signature for cervical cancer through an integrated bioinformatics approach

por Yumei Qi, Yo-Liang Lai, Pei-Chun Shen, Fang-Hsin Chen, Li-Jie Lin, Heng-Hsiung Wu, Pei-Hua Peng, Kai-Wen Hsu, Wei-Chung Cheng
Publicado 2020

Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer

por Domenico Albino, Martina Falcione, Valeria Uboldi, Dada Oluwaseyi Temilola, Giada Sandrini, Jessica Merulla, Gianluca Civenni, Aleksandra Kokanovic, Alessandra Stürchler, Dheeraj Shinde, Mariangela Garofalo, Ricardo Pereira Mestre, Vera Constâncio, Martha Wium, Jacopo Burrello, Nicolò Baranzini, Annalisa Grimaldi, Jean-Philippe Theurillat, Daniela Bossi, Lucio Barile, Rui M. Henrique, Carmen Jeronimo, Luiz Fernando Zerbini, Carlo V. Catapano, Giuseppina M. Carbone
Publicado 2021

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

por Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Jun Yao, Hui Li, Meisi Yan, Wei-Chao Chang, Jung-Mao Hsu, Jong-Ho Cha, Jennifer L. Hsu, Cheng-Wei Chou, Xian Sun, Yalan Deng, Chao-Kai Chou, Dihua Yu, Mien-Chie Hung
Publicado 2021

Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion

por R. Commander, C. Wei, A. Sharma, J. K. Mouw, L. J. Burton, E. Summerbell, D. Mahboubi, R. J. Peterson, J. Konen, W. Zhou, Y. Du, H. Fu, M. Shanmugam, A. I. Marcus
Publicado 2020

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients

por Li Chen, Liu Yang, Ling Yao, Xia-Ying Kuang, Wen-Jia Zuo, Shan Li, Feng Qiao, Yi-Rong Liu, Zhi-Gang Cao, Shu-Ling Zhou, Xiao-Yan Zhou, Wen-Tao Yang, Jin-Xiu Shi, Wei Huang, Xin Hu, Zhi-Ming Shao
Publicado 2018

Deep sequencing and automated histochemistry of human tissue slice cultures improve their usability as preclinical model for cancer research

por Susann Haehnel, Kristin Reiche, Dennis Loeffler, Andreas Horn, Conny Blumert, Sven-Holger Puppel, Nicole Kaiser, Felicitas Rapp, Michael Rade, Friedemann Horn, Juergen Meixensberger, Ingo Bechmann, Frank Gaunitz, Karsten Winter
Publicado 2019

Criteria for identifying residual tumours after neoadjuvant chemotherapy of breast cancers: a magnetic resonance imaging study

por Yunju Kim, Sung Hoon Sim, Boram Park, In Hye Chae, Jai Hong Han, So-Youn Jung, Seeyoun Lee, Youngmi Kwon, In Hae Park, Kyounglan Ko, Chan Wha Lee, Keun Seok Lee, Han-Sung Kang, Eun Sook Lee
Publicado 2021

99mTc-Radiolabeled Silica Nanocarriers for Targeted Detection and Treatment of HER2-Positive Breast Cancer

por Rainone P, De Palma A, Sudati F, Roffia V, Rigamonti V, Salvioni L, Colombo M, Ripamonti M, Spinelli AE, Mazza D, Mauri P, Moresco RM, Prosperi D, Belloli S
Publicado 2021

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer based on network pharmacology and molecular docking

por Xiaoling Li, Baixin Lin, Zhiping Lin, Yucui Ma, Qu Wang, Yushi Zheng, Liao Cui, Hui Luo, Lianxiang Luo
Publicado 2021

National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017

por Cristina Bosetti, Eugenio Traini, Tahiya Alam, Christine A. Allen, Giulia Carreras, Kelly Compton, Christina Fitzmaurice, Lisa M. Force, Silvano Gallus, Giuseppe Gorini, James D. Harvey, Jonathan M. Kocarnik, Carlo La Vecchia, Alessandra Lugo, Mohsen Naghavi, Alyssa Pennini, Cristiano Piccinelli, Luca Ronfani, Rixing Xu, Lorenzo Monasta
Publicado 2020

Impact of intraoperative margin clearance on survival following pancreatoduodenectomy for pancreatic cancer: a systematic review and meta-analysis

por Emrullah Birgin, Erik Rasbach, Patrick Téoule, Felix Rückert, Christoph Reissfelder, Nuh N. Rahbari
Publicado 2020