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  1. 17641
    Evaluation of prediction models for decision-making: beyond calibration and discrimination.
    por Lars Holmberg, Andrew Vickers
    Publicado 2013
    “... to better decision making in light of new research into breast, endometrial, and ovarian cancer risk by Ruth...”
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  2. 17642
    Genomic regression analysis of coordinated expression
    “...Somatic copy number alterations (SCNA) can confound gene co-expression analysis in cancers. Here...”
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  3. 17643
    Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy
    “... for solid cancer therapy. Here, the authors develop a nano-pathogenoid system that targets circulating...”
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  4. 17644
    A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
    “...One strategy to address multidrug resistance in cancer is the development of modular methods...”
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  5. 17645
    Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
    “... cancer cells....”
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  6. 17646
    Structural basis of ligand interaction with atypical chemokine receptor 3
    “...The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer...”
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  7. 17647
    GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
    “... T-cell responses in two syngeneic cancer mouse models....”
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  8. 17648
    Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival
    “...We know that defects in DNA repair genes are associated with cancer development. Here the authors...”
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  9. 17649
    Estimating growth patterns and driver effects in tumor evolution from individual samples
    “...There are many methods to detect cancer-driving mutations. Here, the authors harness the variant...”
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  10. 17650
    Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model
    “... of cancer cell–T cell interactions from each individual patient and the benefits of immunotherapies...”
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  11. 17651
    ELL targets c-Myc for proteasomal degradation and suppresses tumour growth
    “...The expression of the oncogene Myc is carefully controlled and dysregulation often leads to cancer...”
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  12. 17652
    Non-invasive assessment of telomere maintenance mechanisms in brain tumors
    “...Telomerase expression and the alternative lengthening of telomeres pathway are hallmarks of cancer...”
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  13. 17653
    Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging
    “...Non-invasive approaches to stratify early responses to therapy are of great value to improve cancer...”
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  14. 17654
    Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
    “... and cancer....”
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  15. 17655
    Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
    “... that Sirtuin5 promotes glutaminolysis in colorectal cancer cells via glutamate dehydrogenase-1, a critical...”
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  16. 17656
    A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
    “... in breast and lung cancers. In this study, the authors developed a specific monoclonal antibody against...”
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  17. 17657
    The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
    “... of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7...”
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  18. 17658
    NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
    “... of benign lesions but rarely further progression into cancer development. Here the authors use mouse models...”
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  19. 17659
    A positive feedback loop bi-stably activates fibroblasts
    “... and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show...”
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  20. 17660
    Validating the concept of mutational signatures with isogenic cell models
    “... it is possible to recreate cancer mutational signatures in vitro using gene editing experiments in an isogenic...”
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