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  1. 17841
    Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166
    “... that is taken up by endophilin-A3 and galectin-8, which regulates cancer cell migration....”
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  2. 17842
    A Bayesian machine learning approach for drug target identification using diverse data types
    “... molecules, enabling identification of a new set of microtubule inhibitors and the target of the anti-cancer...”
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  3. 17843
    NQO1 inhibits proteasome-mediated degradation of HIF-1α
    “... this contributes to cancer is poorly understood. Here, the authors find that NQO1 competes with PHD proteins...”
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  4. 17844
    Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
    “...Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis...”
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  5. 17845
    C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
    “...In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT...”
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  6. 17846
    In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
    “... effects in mouse models of cancer or viral infection....”
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  7. 17847
    Systems approaches identify the consequences of monosomy in somatic human cells
    “...The mechanisms that allow cancer cells to survive with monosomies are poorly understood. Here...”
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  8. 17848
    Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
    “...Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here...”
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  9. 17849
    Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
    “... single cell sequencing to investigate organoids derived from pancreatic cancer tissue and find a...”
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  10. 17850
    Regulatory T cells control toxicity in a humanized model of IL-2 therapy
    “...High dose IL-2 is a viable treatment option for cancer immune therapy, but the underlying mechanism...”
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  11. 17851
    Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development
    “...FoxO are commonly down-regulated transcription factors and tumor suppressors in renal cell cancer...”
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  12. 17852
    Clonal architectures predict clinical outcome in clear cell renal cell carcinoma
    “...Clear cell renal cell carcinoma (ccRCC) is a urogenital cancer with a well-defined genetic...”
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  13. 17853
    3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations
    “...Chromosome conformation capture techniques enable the study of genome organization in cancer cells...”
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  14. 17854
    An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
    “...Programmed cell death 1 (PD-1) is a key target for cancer immunotherapy. Here the authors present...”
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  15. 17855
    Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
    “... to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient...”
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  16. 17856
    Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
    “...Self-renewal of cancer stem cells can contribute to glioma progression. Here, the authors show...”
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  17. 17857
    Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma
    “...Basal cell carcinoma is a common skin lesion and the risk loci for this cancer are beginning...”
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  18. 17858
    Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy
    “...Radiofrequency ablation is used to treat metastatic colorectal cancer. In this study, the authors...”
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  19. 17859
    Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
    “... multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy....”
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  20. 17860
    Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
    “...The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show...”
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