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  1. 17901
    Retinoblastoma from human stem cell-derived retinal organoids
    “...Retinoblastoma is a heritable pediatric cancer driven by mutations in RB1. Here, the authors...”
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  2. 17902
    MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth
    “...Replication stress is associated with cancer formation and progression. Here the authors reveal...”
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  3. 17903
    G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
    “...ATRX deficiency is linked to genomic stability in cancer cells. Here, the authors show that ATRX...”
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  4. 17904
    Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
    “...The risk of developing cancer increases with age. Here, the authors address the contribution of age...”
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  5. 17905
    Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
    “... that elevated  aerobic glycolysis is not essential for cancer initiation by testing the effect of lactate...”
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  6. 17906
    A genome-wide positioning systems network algorithm for in silico drug repurposing
    “... of cancer type-specific drug responses....”
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  7. 17907
    Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
    “...Cancer therapy drugs are designed to target genetic vulnerabilities, but loss-of-function screens...”
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  8. 17908
    Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
    “...Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds...”
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  9. 17909
    Counting growth factors in single cells with infrared quantum dots to measure discrete stimulation distributions
    “... microscopy to digitally count growth factors in single cells and reveal stimulation distributions in cancer...”
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  10. 17910
    Mutant-selective degradation by BRAF-targeting PROTACs
    “...Hundreds of BRAF mutations have been identified in patients with cancer but currently approved...”
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  11. 17911
    Liquid biopsy tracking during sequential chemo-radiotherapy identifies distinct prognostic phenotypes in nasopharyngeal carcinoma
    “...Liquid biopsies are emerging as a useful method for diagnosis and prognosis in cancer. Here...”
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  12. 17912
    Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
    “... that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered...”
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  13. 17913
    Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
    “... for cancer immunotherapy. Here, the authors design platelet membrane-cloaked nanoparticles for selective...”
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  14. 17914
    The tumor therapy landscape of synthetic lethality
    “... therapy landscape and uncover cancer-specific susceptibilities based on the principle of synthetic...”
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  15. 17915
    Epigenetic modulation reveals differentiation state specificity of oncogene addiction
    “...Epigenetic mechanisms associated with the differentiation state of cancer cells...”
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  16. 17916
    Thermostability profiling of MHC-bound peptides: a new dimension in immunopeptidomics and aid for immunotherapy design
    “... in parallel and a trained artificial neural network to predict immunogenenicity of cancer antigens....”
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  17. 17917
    A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
    “...The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent...”
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  18. 17918
    PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
    “... its anti-cancer effect in leukemic cells expressing the fusion proteins....”
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  19. 17919
    A case of difficult‐to‐diagnose non‐invasive papillary squamous cell carcinoma of the uterine cervix infected with human papilloma virus 6: A diagnostic pitfall
    “...Abstract We encountered HPV6‐positive cervical papillary squamous cancer (PSCC) that was difficult...”
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  20. 17920
    Encountering the Great Problems in the Street: Enacting Hermeneutic Philosophy as Research in Practice Disciplines
    por Graham McCaffrey, Nancy J Moules
    Publicado 2016
    “... such as childhood cancer, grief, mental illness, education and schools, arts and humanities, and other topics...”
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