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  1. 18161
    Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
    “... the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally...”
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  2. 18162
    Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
    “... cancer reveals the evolution of mutational signatures during tumor development, highlighting mutational...”
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  3. 18163
    Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
    “...Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer. Here, the authors...”
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  4. 18164
    Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors
    “...Although Capicua (Cic), a transcriptional repressor, is linked to cancer, little is known about its...”
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  5. 18165
    Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
    “... that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat...”
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  6. 18166
    Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress
    “... for this cancer is unclear. Here, the authors show that, in an NPM–ALK mouse model, the tumours likely arise from...”
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  7. 18167
    DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
    “...T cells derived from stem cells can be harnessed for regenerative medicine and cancer immunotherapy...”
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  8. 18168
    JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression
    “... depletion is sufficient to drive the development of this cancer, where downstream defective MKK7-JNK1/2...”
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  9. 18169
    Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
    “... brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent manner....”
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  10. 18170
    Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
    “...A common failure of many cancer treatments is attributed to the resistance imparted by tumour...”
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  11. 18171
    ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
    “.... Here, analysing genome-wide chromatin associations, the authors show that in breast cancer cells ZNF516...”
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  12. 18172
    Mutant KRAS promotes malignant pleural effusion formation
    “...Malignant pleural effusion (MPE) is a lethal condition associated with various cancers. Here...”
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  13. 18173
    PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma
    “... and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection...”
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  14. 18174
    Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
    “... is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene...”
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  15. 18175
    Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance
    “... the growth-inducing effect of p53 overexpression and ionising irradiation in human cancer lines in culture...”
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  16. 18176
    T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
    “... lung cancer treated with anti-PD-1....”
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  17. 18177
    Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
    “... show that IL-35 is overexpressed by human pancreatic cancer cells and show, in a mouse model, that IL...”
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  18. 18178
    Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
    “...Cancer cells adapt their metabolism to survive limited nutrient availability. Here, the authors...”
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  19. 18179
    Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
    “..., the authors show that tamoxifen, a drug used to treat breast cancer, rescues the pathology in a mouse model...”
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  20. 18180
    Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
    “...JmjC histone demethylases (KDMs) are cancer targets due to their links to cell proliferation...”
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