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  1. 18401
    Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT
    “..., but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen...”
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  2. 18402
    On-target restoration of a split T cell-engaging antibody for precision immunotherapy
    “... in preclinical leukemia and breast cancer mouse models....”
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  3. 18403
    Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
    “... models of cancer. Here the authors compare sarcomas generated using both systems and see similar genetic...”
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  4. 18404
    Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution
    “...Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment...”
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  5. 18405
    Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model
    “... cancer (CRPC-NE). Here, the authors develop patient-derived model from circulating tumor cells of a CRPC...”
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  6. 18406
    Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
    “...Activated PI3K causes cancer, but the role of active PI3K mutations in early stages of malignancy...”
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  7. 18407
    Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
    “...Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors...”
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  8. 18408
    Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
    “...Lung cancer etiology has largely been studied in homogenous populations of European descent. Here...”
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  9. 18409
    A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology
    “...A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute...”
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  10. 18410
    Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
    “...Pan, Chen, Zhang et al. investigated the anti-cancer efficacy of CA170, a small molecule agonist...”
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  11. 18411
    Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
    “...Abstract Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan...”
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  12. 18412
    Correction: Author Correction: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
    “... was also supported by a grant to Y.H. from the Cancer Prevention Research Institute of Texas CPRIT RP170126....”
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  13. 18413
    The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival
    “..., the authors reveal a role for the histone demethylase KDM3A in the survival of this haematologic cancer...”
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  14. 18414
    The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
    “...The treatment of ROS1-rearranged non-small cell lung cancer with the TKI crizotinib is limited due...”
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  15. 18415
    Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
    “...Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors...”
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  16. 18416
    Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain
    “... plasticity during development and the adaptation of cancer cells to adverse environments....”
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  17. 18417
    Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
    “... resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway....”
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  18. 18418
    Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
    “...CRISPR-based knockout screens in cancer cells have suggested the existence of proliferation...”
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  19. 18419
    Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
    por Muwen Kong, Eric C. Greene
    Publicado 2021
    “... unrepaired, they are detrimental to genome stability, leading to high risk of cancer. Two major mechanisms...”
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  20. 18420
    INFLUENCE OF IMMUNOMODULATING AGENTS IMMUNOVAK VP-4 AND PROFETAL ON FUNCTIONAL ACTIVITY OF MONONUCLEAR LEUKOCYTES
    “... and natural killer T-cells. Both bio-active preparations possess an expressed anti-cancer effect in vitro, i.e...”
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