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  1. 18461
    The driver landscape of sporadic chordoma
    “... brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma....”
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  2. 18462
    A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
    “..., such as cancer, but remain poorly characterized as a family. Here, the authors provide a comprehensive analysis...”
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  3. 18463
    Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
    “... that in hepatocellular carcinoma, hypoxia induces the expression of ENTPD2 on cancer cells leading to elevated...”
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  4. 18464
    Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
    “...Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding...”
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  5. 18465
    A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
    “...The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2...”
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  6. 18466
    Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,
    “...Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based...”
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  7. 18467
    Photo-enhanced Aqueous Solubilization of an Azo-compound
    “... reversibly switch the aqueous solubilization of an anti-cancer candidate drug, a low-molecular-weight kinase...”
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  8. 18468
    Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
    “... degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tissues....”
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  9. 18469
    Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
    “... this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology....”
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  10. 18470
    High-resolution label-free 3D mapping of extracellular pH of single living cells
    “... mapping in live cancer cells....”
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  11. 18471
    Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
    “...Promising results of cancer therapies in transplant tumor models often fail to predict efficacy...”
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  12. 18472
    Label-free Electrochemical Detection of ATP Based on Amino-functionalized Metal-organic Framework
    “... in serum of cancer patients, which reveals its potential application in clinical diagnosis....”
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  13. 18473
    miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
    “...Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome...”
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  14. 18474
    Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC
    “...Treatment of EGFR mutant non-small cell lung cancer (NSCLC) often develops resistance to EGFR TKIs...”
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  15. 18475
    Loss of GCNT2/I-branched glycans enhances melanoma growth and survival
    “...Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions...”
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  16. 18476
    Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
    “... adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics....”
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  17. 18477
    A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control
    “...Interleukin-2 (IL-2) based cancer therapy is limited by severe toxicity and strong Treg...”
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  18. 18478
    Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
    “...Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state...”
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  19. 18479
    Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
    “...When examining the evolution of treatment resistance in breast cancer, perceived genomic changes...”
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  20. 18480
    Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
    “... APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted...”
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