Mostrando 781 - 800 Resultados de 1,137 Para Buscar '"CRISPR"', tiempo de consulta: 0.07s Limitar resultados
  1. 781
    Multiplexed Cas9 targeting reveals genomic location effects and gRNA-based staggered breaks influencing mutation efficiency
    “... that genomic locus has on CRISPR-Cas9 activity. Here the authors use TRIP integrations to profile editing...”
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  2. 782
    Overlapping roles of spliceosomal components SF3B1 and PHF5A in rice splicing regulation
    “...Butt et al. used CRISPR-mediated directed evolution to generate rice mutants for the spliceosome...”
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  3. 783
    Highly efficient baculovirus-mediated multigene delivery in primary cells
    “... delivery into a wide variety of cells, and use Multiprime for genome engineering by CRISPR/Cas9....”
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  4. 784
    Identification of potential chemical compounds enhancing generation of enucleated cells from immortalized human erythroid cell lines
    “..., SPTA1, is downregulated in HDAC inhibited cells and that restoration of SPTA1 expression using CRISPR...”
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  5. 785
    Phenotypic analysis of catastrophic childhood epilepsy genes
    “...Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing...”
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  6. 786
    Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
    “... primase plays part in tandem duplication formation at CRISPR/Cas9-induced complementary 3′ ssDNA...”
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  7. 787
    Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
    “... on PRISM and high-throughput CRISPR/Cas9 loss-of-function screen technologies using cell line barcoding....”
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  8. 788
    CYP6AE gene cluster knockout in Helicoverpa armigera reveals role in detoxification of phytochemicals and insecticides
    “... insecticides through the CRISPR-Cas9-based reverse genetics approach in conjunction with in vitro metabolism....”
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  9. 789
    Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
    “...While CRISPR-Cas9 is a powerful technology, it’sin vivoapplication can be limited by unwanted off...”
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  10. 790
    A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
    “... CRISPR gene editing, ATAC-seq and ChIP-seq, that specific Runx1-bound enhancer elements critically...”
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  11. 791
    Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers
    “... the authors performed a CRISPR-selective vulnerability screen to identify transaldoloase as a target...”
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  12. 792
    CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data
    “...The control of off-target activity is a challenge for adapting CRISPR to therapeutic use. Here...”
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  13. 793
    Gene editing enables rapid engineering of complex antibiotic assembly lines
    “... but is challenging with current methods. Here the authors use CRISPR-Cas9 to exchange subdomains within NRPS to alter...”
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  14. 794
    Cas9-AAV6 gene correction of beta-globin in autologous HSCs improves sickle cell disease erythropoiesis in mice
    “...CRISPR mediated gene correction of sickle cell disease (SCD) in patient-derived hematopoietic stem...”
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  15. 795
    PrimeDesign software for rapid and simplified design of prime editing guide RNAs
    “...Prime editing guide RNA design is more complex than for standard CRISPR-based nucleases or base...”
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  16. 796
    Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9
    “... and its target DNA, which is of interest for engineering of CRISPR-Cas9 genome-editor nucleases....”
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  17. 797
    Versatile protein tagging in cells with split fluorescent protein
    “... into genomic loci using CRISPR/Cas9....”
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  18. 798
    Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
    “... microhomologies. Here the authors use CRISPR-Cas9 to recreate pathogenic deletion mutations using existing...”
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  19. 799
    Genetic determinants of cellular addiction to DNA polymerase theta
    “.... Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce...”
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  20. 800
    Rice <italic toggle="yes">SST</italic> Variation Shapes the Rhizosphere Bacterial Community, Conferring Tolerance to Salt Stress through Regulating Soil Metabolites
    “...) and Zhonghua 11 (ZH11) cultivars by the CRISPR/Cas9 system and found that loss of SST function increased...”
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