Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a

por Jinwei Zhang, Mohammad Iqbal H. Bhuiyan, Ting Zhang, Jason K. Karimy, Zhijuan Wu, Victoria M. Fiesler, Jingfang Zhang, Huachen Huang, Md Nabiul Hasan, Anna E. Skrzypiec, Mariusz Mucha, Daniel Duran, Wei Huang, Robert Pawlak, Lesley M. Foley, T. Kevin Hitchens, Margaret B. Minnigh, Samuel M. Poloyac, Seth L. Alper, Bradley J. Molyneaux, Andrew J. Trevelyan, Kristopher T. Kahle, Dandan Sun, Xianming Deng
Publicado 2020

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

por Adam K. Wheatley, Jennifer A. Juno, Jing J. Wang, Kevin J. Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M. Wragg, Hannah G. Kelly, Robyn Esterbauer, Samantha K. Davis, Helen E. Kent, Francesca L. Mordant, Timothy E. Schlub, David L. Gordon, David S. Khoury, Kanta Subbarao, Deborah Cromer, Tom P. Gordon, Amy W. Chung, Miles P. Davenport, Stephen J. Kent
Publicado 2021

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

por Kevin O. Saunders, Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, Maggie Barr, Amanda Eaton, Giovanna Hernandez, Derrick Goodman, Michael J. Hogan, Istvan Tombacz, David N. Gordon, R. Wes Rountree, Yunfei Wang, Mark G. Lewis, Theodore C. Pierson, Chris Barbosa, Ying Tam, Xiaoying Shen, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, Drew Weissman, Barton F. Haynes
Publicado 2021

High-resolution characterization of gene function using single-cell CRISPR tiling screen

por Lu Yang, Anthony K. N. Chan, Kazuya Miyashita, Christopher D. Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T. Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A. Armstrong, Chun-Wei Chen
Publicado 2021

Dynamic sex chromosome expression in Drosophila male germ cells

por Sharvani Mahadevaraju, Justin M. Fear, Miriam Akeju, Brian J. Galletta, Mara M. L. S. Pinheiro, Camila C. Avelino, Diogo C. Cabral-de-Mello, Katie Conlon, Stafania Dell’Orso, Zelalem Demere, Kush Mansuria, Carolina A. Mendonça, Octavio M. Palacios-Gimenez, Eli Ross, Max Savery, Kevin Yu, Harold E. Smith, Vittorio Sartorelli, Haiwang Yang, Nasser M. Rusan, Maria D. Vibranovski, Erika Matunis, Brian Oliver
Publicado 2021

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

por Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler, Naomi P. Visanji, Connie Marras, Nour K. Majbour, Omar M. A. El-Agnaf, Andres M. Lozano, Joseph Culotti, Satoshi Suo, William S. Ryu, Suneil K. Kalia, Lorraine V. Kalia
Publicado 2021

Characterization of oral swab samples for diagnosis of pulmonary tuberculosis.

por Rachel C Wood, Alfred Andama, Gleda Hermansky, Stephen Burkot, Lucy Asege, Mukwatamundu Job, David Katumba, Martha Nakaye, Sandra Z Mwebe, Jerry Mulondo, Christine M Bachman, Kevin P Nichols, Anne-Laure M Le Ny, Corrie Ortega, Rita N Olson, Kris M Weigel, Alaina M Olson, Damian Madan, David Bell, Adithya Cattamanchi, William Worodria, Fred C Semitala, Akos Somoskovi, Gerard A Cangelosi, Kyle J Minch
Publicado 2021

A Strategy To Estimate Unknown Viral Diversity in Mammals

por Simon J. Anthony, Jonathan H. Epstein, Kris A. Murray, Isamara Navarrete-Macias, Carlos M. Zambrana-Torrelio, Alexander Solovyov, Rafael Ojeda-Flores, Nicole C. Arrigo, Ariful Islam, Shahneaz Ali Khan, Parviez Hosseini, Tiffany L. Bogich, Kevin J. Olival, Maria D. Sanchez-Leon, William B. Karesh, Tracey Goldstein, Stephen P. Luby, Stephen S. Morse, Jonna A. K. Mazet, Peter Daszak, W. Ian Lipkin
Publicado 2013

Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux.

por Nicola K Petty, Theresa Feltwell, Derek Pickard, Simon Clare, Ana L Toribio, Maria Fookes, Kevin Roberts, Rita Monson, Satheesh Nair, Robert A Kingsley, Richard Bulgin, Siouxsie Wiles, David Goulding, Thomas Keane, Craig Corton, Nicola Lennard, David Harris, David Willey, Richard Rance, Lu Yu, Jyoti S Choudhary, Carol Churcher, Michael A Quail, Julian Parkhill, Gad Frankel, Gordon Dougan, George P C Salmond, Nicholas R Thomson
Publicado 2011

Timing the initiation of multiple myeloma

por Even H. Rustad, Venkata Yellapantula, Daniel Leongamornlert, Niccolò Bolli, Guy Ledergor, Ferran Nadeu, Nicos Angelopoulos, Kevin J. Dawson, Thomas J. Mitchell, Robert J. Osborne, Bachisio Ziccheddu, Cristiana Carniti, Vittorio Montefusco, Paolo Corradini, Kenneth C. Anderson, Philippe Moreau, Elli Papaemmanuil, Ludmil B. Alexandrov, Xose S. Puente, Elias Campo, Reiner Siebert, Herve Avet-Loiseau, Ola Landgren, Nikhil Munshi, Peter J. Campbell, Francesco Maura
Publicado 2020

Diversity analysis of 80,000 wheat accessions reveals consequences and opportunities of selection footprints

por Carolina Sansaloni, Jorge Franco, Bruno Santos, Lawrence Percival-Alwyn, Sukhwinder Singh, Cesar Petroli, Jaime Campos, Kate Dreher, Thomas Payne, David Marshall, Benjamin Kilian, Iain Milne, Sebastian Raubach, Paul Shaw, Gordon Stephen, Jason Carling, Carolina Saint Pierre, Juan Burgueño, José Crosa, HuiHui Li, Carlos Guzman, Zakaria Kehel, Ahmed Amri, Andrzej Kilian, Peter Wenzl, Cristobal Uauy, Marianne Banziger, Mario Caccamo, Kevin Pixley
Publicado 2020

The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

por Bin Zhu, Maria Luana Poeta, Manuela Costantini, Tongwu Zhang, Jianxin Shi, Steno Sentinelli, Wei Zhao, Vincenzo Pompeo, Maurizio Cardelli, Boian S. Alexandrov, Burcak Otlu, Xing Hua, Kristine Jones, Seth Brodie, Malgorzata Ewa Dabrowska, Jorge R. Toro, Meredith Yeager, Mingyi Wang, Belynda Hicks, Ludmil B. Alexandrov, Kevin M. Brown, David C. Wedge, Stephen Chanock, Vito Michele Fazio, Michele Gallucci, Maria Teresa Landi
Publicado 2020

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

por Jan R. Kraehling, John H. Chidlow, Chitra Rajagopal, Michael G. Sugiyama, Joseph W. Fowler, Monica Y. Lee, Xinbo Zhang, Cristina M. Ramírez, Eon Joo Park, Bo Tao, Keyang Chen, Leena Kuruvilla, Bruno Larriveé, Ewa Folta-Stogniew, Roxana Ola, Noemi Rotllan, Wenping Zhou, Michael W. Nagle, Joachim Herz, Kevin Jon Williams, Anne Eichmann, Warren L. Lee, Carlos Fernández-Hernando, William C. Sessa
Publicado 2016

AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines

por Liyang Zhang, John A. Zuris, Ramya Viswanathan, Jasmine N. Edelstein, Rolf Turk, Bernice Thommandru, H. Tomas Rube, Steve E. Glenn, Michael A. Collingwood, Nicole M. Bode, Sarah F. Beaudoin, Swarali Lele, Sean N. Scott, Kevin M. Wasko, Steven Sexton, Christopher M. Borges, Mollie S. Schubert, Gavin L. Kurgan, Matthew S. McNeill, Cecilia A. Fernandez, Vic E. Myer, Richard A. Morgan, Mark A. Behlke, Christopher A. Vakulskas
Publicado 2021

Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters

por Kaixi Zhang, Yu Du, Zhangyong Si, Yang Liu, Michelle E. Turvey, Cheerlavancha Raju, Damien Keogh, Lin Ruan, Subramanion L. Jothy, Sheethal Reghu, Kalisvar Marimuthu, Partha Pratim De, Oon Tek Ng, José R. Mediavilla, Barry N. Kreiswirth, Yonggui Robin Chi, Jinghua Ren, Kam C. Tam, Xue-Wei Liu, Hongwei Duan, Yabin Zhu, Yuguang Mu, Paula T. Hammond, Guillermo C. Bazan, Kevin Pethe, Mary B. Chan-Park
Publicado 2019

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

por Francesco Maura, Niccoló Bolli, Nicos Angelopoulos, Kevin J. Dawson, Daniel Leongamornlert, Inigo Martincorena, Thomas J. Mitchell, Anthony Fullam, Santiago Gonzalez, Raphael Szalat, Federico Abascal, Bernardo Rodriguez-Martin, Mehmet Kemal Samur, Dominik Glodzik, Marco Roncador, Mariateresa Fulciniti, Yu Tzu Tai, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth C. Anderson, Jose M. C. Tubio, David C. Wedge, Moritz Gerstung, Hervé Avet-Loiseau, Nikhil Munshi, Peter J. Campbell
Publicado 2019

Genome maps across 26 human populations reveal population-specific patterns of structural variation

por Michal Levy-Sakin, Steven Pastor, Yulia Mostovoy, Le Li, Alden K. Y. Leung, Jennifer McCaffrey, Eleanor Young, Ernest T. Lam, Alex R. Hastie, Karen H. Y. Wong, Claire Y. L. Chung, Walfred Ma, Justin Sibert, Ramakrishnan Rajagopalan, Nana Jin, Eugene Y. C. Chow, Catherine Chu, Annie Poon, Chin Lin, Ahmed Naguib, Wei-Ping Wang, Han Cao, Ting-Fung Chan, Kevin Y. Yip, Ming Xiao, Pui-Yan Kwok
Publicado 2019

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

por Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publicado 2019

Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

por George B. Saffouri, Robin R. Shields-Cutler, Jun Chen, Yi Yang, Heather R. Lekatz, Vanessa L. Hale, Janice M. Cho, Eric J. Battaglioli, Yogesh Bhattarai, Kevin J. Thompson, Krishna K. Kalari, Gaurav Behera, Jonathan C. Berry, Stephanie A. Peters, Robin Patel, Audrey N. Schuetz, Jeremiah J. Faith, Michael Camilleri, Justin L. Sonnenburg, Gianrico Farrugia, Jonathan R. Swann, Madhusudan Grover, Dan Knights, Purna C. Kashyap
Publicado 2019

NQO1 protects obese mice through improvements in glucose and lipid metabolism

por Andrea Di Francesco, Youngshim Choi, Michel Bernier, Yingchun Zhang, Alberto Diaz-Ruiz, Miguel A. Aon, Krystle Kalafut, Margaux R. Ehrlich, Kelsey Murt, Ahmed Ali, Kevin J. Pearson, Sophie Levan, Joshua D. Preston, Alejandro Martin-Montalvo, Jennifer L. Martindale, Kotb Abdelmohsen, Cole R. Michel, Diana M. Willmes, Christine Henke, Placido Navas, Jose Manuel Villalba, David Siegel, Myriam Gorospe, Kristofer Fritz, Shyam Biswal, David Ross, Rafael de Cabo
Publicado 2020