Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

by Samuel Terkper Ahuno, Anna-Lisa Doebley, Thomas U. Ahearn, Joel Yarney, Nicholas Titiloye, Nancy Hamel, Ernest Adjei, Joe-Nat Clegg-Lamptey, Lawrence Edusei, Baffour Awuah, Xiaoyu Song, Verna Vanderpuye, Mustapha Abubakar, Maire Duggan, Daniel G. Stover, Kofi Nyarko, John M. S. Bartlett, Francis Aitpillah, Daniel Ansong, Kevin L. Gardner, Felix Andy Boateng, Anne M. Bowcock, Carlos Caldas, William D. Foulkes, Seth Wiafe, Beatrice Wiafe-Addai, Montserrat Garcia-Closas, Alexander Kwarteng, Gavin Ha, Jonine D. Figueroa, Paz Polak, the Ghana Breast Health Study Team
Published 2021

Protein truncating variants in FANCM and risk for ER-negative/triple negative breast cancer

by Paolo Peterlongo, Gisella Figlioli, Andrew J. Deans, Fergus J. Couch
Published 2021

Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer (“METRIC”): a randomized multicenter study

by Linda T. Vahdat, Peter Schmid, Andres Forero-Torres, Kimberly Blackwell, Melinda L. Telli, Michelle Melisko, Volker Möbus, Javier Cortes, Alberto J. Montero, Cynthia Ma, Rita Nanda, Gail S. Wright, Yi He, Thomas Hawthorne, Rebecca G. Bagley, Abdel-Baset Halim, Christopher D. Turner, Denise A. Yardley
Published 2021

HER2-positive breast cancer and tyrosine kinase inhibitors: the time is now

by Ilana Schlam, Sandra M. Swain
Published 2021

Deep learning for diagnosis of acute promyelocytic leukemia via recognition of genomically imprinted morphologic features

by John-William Sidhom, Ingharan J. Siddarthan, Bo-Shiun Lai, Adam Luo, Bryan C. Hambley, Jennifer Bynum, Amy S. Duffield, Michael B. Streiff, Alison R. Moliterno, Philip Imus, Christian B. Gocke, Lukasz P. Gondek, Amy E. DeZern, Alexander S. Baras, Thomas Kickler, Mark J. Levis, Eugene Shenderov
Published 2021

GnRHa protects the ovarian reserve by reducing endoplasmic reticulum stress during cyclophosphamide-based chemotherapy

by Xiaolin Li, Sixuan Liu, Xuan Chen, Run Huang, Lisi Ma, Huaiyu Weng, Yang Yu, Xiangyun Zong
Published 2021

Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects

by Na Li, Magnus Zethoven, Simone McInerny, Lisa Devereux, Yu-Kuan Huang, Niko Thio, Dane Cheasley, Sara Gutiérrez-Enríquez, Alejandro Moles-Fernández, Orland Diez, Tu Nguyen-Dumont, Melissa C. Southey, John L. Hopper, Jacques Simard, Martine Dumont, Penny Soucy, Alfons Meindl, Rita Schmutzler, Marjanka K. Schmidt, Muriel A. Adank, Irene L. Andrulis, Eric Hahnen, Christoph Engel, Fabienne Lesueur, Elodie Girard, Susan L. Neuhausen, Elad Ziv, Jamie Allen, Douglas F. Easton, Rodney J. Scott, Kylie L. Gorringe, Paul A. James, Ian G. Campbell
Published 2021

Epigenomics and immunotherapeutic advances in pediatric brain tumors

by Malak Abedalthagafi, Nahla Mobark, May Al-Rashed, Musa AlHarbi
Published 2021

Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge

by Grace G. Bushnell, Abhijeet P. Deshmukh, Petra den Hollander, Ming Luo, Rama Soundararajan, Dongya Jia, Herbert Levine, Sendurai A. Mani, Max S. Wicha
Published 2021

How can artificial intelligence models assist PD-L1 expression scoring in breast cancer: results of multi-institutional ring studies

by Xinran Wang, Liang Wang, Hong Bu, Ningning Zhang, Meng Yue, Zhanli Jia, Lijing Cai, Jiankun He, Yanan Wang, Xin Xu, Shengshui Li, Kaiwen Xiao, Kezhou Yan, Kuan Tian, Xiao Han, Junzhou Huang, Jianhua Yao, Yueping Liu
Published 2021

Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors

by Leah Puklin, Brenda Cartmel, Maura Harrigan, Lingeng Lu, Fang-yong Li, Tara Sanft, Melinda L. Irwin
Published 2021

Impact of estrogen receptor levels on outcome in non-metastatic triple negative breast cancer patients treated with neoadjuvant/adjuvant chemotherapy

by Maria Vittoria Dieci, Gaia Griguolo, Michele Bottosso, Vassilena Tsvetkova, Carlo Alberto Giorgi, Grazia Vernaci, Silvia Michieletto, Silvia Angelini, Alberto Marchet, Giulia Tasca, Elisa Genovesi, Enrico Cumerlato, Marcello Lo Mele, PierFranco Conte, Valentina Guarneri
Published 2021

Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients

by Sasha E. Stanton, Ekram Gad, Erik Ramos, Lauren Corulli, James Annis, Jennifer Childs, Hiroyuki Katayama, Samir Hanash, Jeffrey Marks, Mary L. Disis
Published 2021

Circulating cell-free DNA-based methylation patterns for breast cancer diagnosis

by Xianyu Zhang, Dezhi Zhao, Yanling Yin, Ting Yang, Zilong You, Dalin Li, Yanbo Chen, Yongdong Jiang, Shouping Xu, Jingshu Geng, Yashuang Zhao, Jun Wang, Hui Li, Jinsheng Tao, Shan Lei, Zeyu Jiang, Zhiwei Chen, Shihui Yu, Jian-Bing Fan, Da Pang
Published 2021

Anti-tumor effects of an ID antagonist with no observed acquired resistance

by Paulina M. Wojnarowicz, Marta Garcia Escolano, Yun-Han Huang, Bina Desai, Yvette Chin, Riddhi Shah, Sijia Xu, Saurabh Yadav, Sergey Yaklichkin, Ouathek Ouerfelli, Rajesh Kumar Soni, John Philip, David C. Montrose, John H. Healey, Vinagolu K. Rajasekhar, William A. Garland, Jeremy Ratiu, Yuan Zhuang, Larry Norton, Neal Rosen, Ronald C. Hendrickson, Xi Kathy Zhou, Antonio Iavarone, Joan Massague, Andrew J. Dannenberg, Anna Lasorella, Robert Benezra
Published 2021

Modulation of the immune microenvironment of high-risk ductal carcinoma in situ by intralesional pembrolizumab injection

by Alexa C. Glencer, Jasmine M. Wong, Nola M. Hylton, Gregor Krings, Emma McCune, Harriet T. Rothschild, Tristan A. Loveday, Michael D. Alvarado, Laura J. Esserman, Michael J. Campbell
Published 2021

Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ

by Mathilde M. M. Almekinders, Michael Schaapveld, Bram Thijssen, Lindy L. Visser, Tycho Bismeijer, Joyce Sanders, Edoardo Isnaldi, Ingrid Hofland, Marjolijn Mertz, Lodewyk F. A. Wessels, Annegien Broeks, Erik Hooijberg, Wilbert Zwart, Esther H. Lips, Grand Challenge PRECISION Consortium, Christine Desmedt, Jelle Wesseling
Published 2021

Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes

by Kirby P. Gardner, Mohammed Aldakkak, Cha-Mei Tang, Susan Tsai, Daniel L. Adams
Published 2021

PONDx: real-life utilization and decision impact of the 21-gene assay on clinical practice in Italy

by Francesco Cognetti, Riccardo Masetti, Alessandra Fabi, Giulia Bianchi, Donatella Santini, Alessia Rognone, Giovanna Catania, Domenico Angelucci, Giuseppe Naso, Mario Giuliano, Lucia Vassalli, Patrizia Vici, Giovanni Scognamiglio, Daniele Generali, Alberto Zambelli, Marco Colleoni, Corrado Tinterri, Francesco Scanzi, Leonardo Vigna, Paola Scavina, Teresa Gamucci, Emilia Marrazzo, Angelo Fedele Scinto, Rossana Berardi, Maria Agnese Fabbri, Graziella Pinotti, Daniela Franco, Daniela Andreina Terribile, Giuseppe Tonini, Daniela Cianniello, Sandro Barni
Published 2021

A genomic mutation signature predicts the clinical outcomes of immunotherapy and characterizes immunophenotypes in gastrointestinal cancer

by Xi Jiao, Xin Wei, Shuang Li, Chang Liu, Huan Chen, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yujiao Wang, Yanni Wang, Na Zhuo, Henghui Zhang, Zhihao Lu, Lin Shen
Published 2021