MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies

por Andrew D. White, Laura Sibley, Charlotte Sarfas, Alexandra Morrison, Jennie Gullick, Simon Clark, Fergus Gleeson, Anthony McIntyre, Cecilia Lindestam Arlehamn, Alessandro Sette, Francisco J. Salguero, Emma Rayner, Esteban Rodriguez, Eugenia Puentes, Dominick Laddy, Ann Williams, Mike Dennis, Carlos Martin, Sally Sharpe
Publicado 2021

Investigating the origins of eastern Polynesians using genome-wide data from the Leeward Society Isles

por Georgi Hudjashov, Phillip Endicott, Helen Post, Nano Nagle, Simon Y. W. Ho, Daniel J. Lawson, Maere Reidla, Monika Karmin, Siiri Rootsi, Ene Metspalu, Lauri Saag, Richard Villems, Murray P. Cox, R. John Mitchell, Ralph L. Garcia-Bertrand, Mait Metspalu, Rene J. Herrera
Publicado 2018

Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

por Simon T. Bond, Emily J. King, Darren C. Henstridge, Adrian Tran, Sarah C. Moody, Christine Yang, Yingying Liu, Natalie A. Mellett, Artika P. Nath, Michael Inouye, Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Peter J. Meikle, Anna C. Calkin, Brian G. Drew
Publicado 2021

Epidemiological hypothesis testing using a phylogeographic and phylodynamic framework

por Simon Dellicour, Sebastian Lequime, Bram Vrancken, Mandev S. Gill, Paul Bastide, Karthik Gangavarapu, Nathaniel L. Matteson, Yi Tan, Louis du Plessis, Alexander A. Fisher, Martha I. Nelson, Marius Gilbert, Marc A. Suchard, Kristian G. Andersen, Nathan D. Grubaugh, Oliver G. Pybus, Philippe Lemey
Publicado 2020

An effector from the Huanglongbing-associated pathogen targets citrus proteases

por Kelley Clark, Jessica Yvette Franco, Simon Schwizer, Zhiqian Pang, Eva Hawara, Thomas W. H. Liebrand, Deborah Pagliaccia, Liping Zeng, Fatta B. Gurung, Pengcheng Wang, Jinxia Shi, Yinsheng Wang, Veronica Ancona, Renier A. L. van der Hoorn, Nian Wang, Gitta Coaker, Wenbo Ma
Publicado 2018

Remote ischemic preconditioning improves tissue oxygenation in a porcine model of controlled hemorrhage without fluid resuscitation

por Gal Yaniv, Arik Eisenkraft, Lilach Gavish, Linn Wagnert-Avraham, Dean Nachman, Jacob Megreli, Gil Shimon, Daniel Rimbrot, Ben Simon, Asaf Berman, Matan Cohen, David Kushnir, Ruth Shaylor, Baruch Batzofin, Shimon Firman, Amir Shlaifer, Michael Hartal, Yuval Heled, Elon Glassberg, Yitshak Kreiss, S. David Gertz
Publicado 2021

Multi-level quantum noise spectroscopy

por Youngkyu Sung, Antti Vepsäläinen, Jochen Braumüller, Fei Yan, Joel I-Jan Wang, Morten Kjaergaard, Roni Winik, Philip Krantz, Andreas Bengtsson, Alexander J. Melville, Bethany M. Niedzielski, Mollie E. Schwartz, David K. Kim, Jonilyn L. Yoder, Terry P. Orlando, Simon Gustavsson, William D. Oliver
Publicado 2021

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

por Hélène Choquet, Seyyedhassan Paylakhi, Stephen C. Kneeland, Khanh K. Thai, Thomas J. Hoffmann, Jie Yin, Mark N. Kvale, Yambazi Banda, Nicholas G. Tolman, Pete A. Williams, Catherine Schaefer, Ronald B. Melles, Neil Risch, Simon W. M. John, K. Saidas Nair, Eric Jorgenson
Publicado 2018

SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization

por Nkerorema Djodji Damas, Michela Marcatti, Christophe Côme, Lise Lotte Christensen, Morten Muhlig Nielsen, Roland Baumgartner, Helene Maria Gylling, Giulia Maglieri, Carsten Friis Rundsten, Stefan E. Seemann, Nicolas Rapin, Simon Thézenas, Søren Vang, Torben Ørntoft, Claus Lindbjerg Andersen, Jakob Skou Pedersen, Anders H. Lund
Publicado 2016

Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

por Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese
Publicado 2021

Oncologic trogocytosis of an original stromal cells induces chemoresistance of ovarian tumours.

por Arash Rafii, Pejman Mirshahi, Mary Poupot, Anne-Marie Faussat, Anne Simon, Elodie Ducros, Eliane Mery, Bettina Couderc, Raphael Lis, Jerome Capdet, Julie Bergalet, Denis Querleu, Francoise Dagonnet, Jean-Jacques Fournié, Jean-Pierre Marie, Eric Pujade-Lauraine, Gilles Favre, Jeanine Soria, Massoud Mirshahi
Publicado 2008

Development and validation of a weakly supervised deep learning framework to predict the status of molecular pathways and key mutations in colorectal cancer from routine histology...

por Mohsin Bilal, PhD, Shan E Ahmed Raza, PhD, Ayesha Azam, MBBS, Simon Graham, PhD, Mohammad Ilyas, ProfPhD, Ian A Cree, ProfPhD, David Snead, ProfMBBS, Fayyaz Minhas, PhD, Nasir M Rajpoot, ProfPhD
Publicado 2021

Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis.

por Petroula Proitsi, Michelle K Lupton, Latha Velayudhan, Stephen Newhouse, Isabella Fogh, Magda Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Alzheimer's Disease Neuroimaging Initiative, Julie Williams, GERAD1 Consortium, Robert Stewart, Pak Sham, Simon Lovestone, John F Powell
Publicado 2014

A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease.

por Daniel Todd, Ian Gowers, Simon J Dowler, Michael D Wall, George McAllister, David F Fischer, Sipke Dijkstra, Silvina A Fratantoni, Rhea van de Bospoort, Jessica Veenman-Koepke, Geraldine Flynn, Jamshid Arjomand, Celia Dominguez, Ignacio Munoz-Sanjuan, John Wityak, Jonathan A Bard
Publicado 2014

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

por Simon Haworth, Chin Yang Shapland, Caroline Hayward, Bram P. Prins, Janine F. Felix, Carolina Medina-Gomez, Fernando Rivadeneira, Carol Wang, Tarunveer S. Ahluwalia, Martine Vrijheid, Mònica Guxens, Jordi Sunyer, Ioanna Tachmazidou, Klaudia Walter, Valentina Iotchkova, Andrew Jackson, Louise Cleal, Jennifer Huffmann, Josine L. Min, Lærke Sass, Paul R. H. J. Timmers, UK10K consortium, George Davey Smith, Simon E. Fisher, James F. Wilson, Tim J. Cole, Dietmar Fernandez-Orth, Klaus Bønnelykke, Hans Bisgaard, Craig E. Pennell, Vincent W. V. Jaddoe, George Dedoussis, Nicholas Timpson, Eleftheria Zeggini, Veronique Vitart, Beate St Pourcain
Publicado 2019

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

por Stephan M. Tirier, Jan-Philipp Mallm, Simon Steiger, Alexandra M. Poos, Mohamed H. S. Awwad, Nicola Giesen, Nicola Casiraghi, Hana Susak, Katharina Bauer, Anja Baumann, Lukas John, Anja Seckinger, Dirk Hose, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Michael Hundemer, Niels Weinhold, Marc S. Raab, Karsten Rippe
Publicado 2021

Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.

por Lydia Quaye, Jonathan Tyrer, Susan J Ramus, Honglin Song, Eva Wozniak, Richard A DiCioccio, Valerie McGuire, Estrid Høgdall, Claus Høgdall, Jan Blaakaer, Ellen L Goode, Joellen M Schildkraut, Douglas F Easton, Susanne Krüger-Kjaer, Alice S Whittemore, Simon A Gayther, Paul D P Pharoah
Publicado 2009

Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.

por Liam A Ridge, Karen Mitchell, Ali Al-Anbaki, Wasay Mohiuddin Shaikh Qureshi, Louise A Stephen, Gennadiy Tenin, Yinhui Lu, Irina-Elena Lupu, Christopher Clowes, Abigail Robertson, Emma Barnes, Jayne A Wright, Bernard Keavney, Elisabeth Ehler, Simon C Lovell, Karl E Kadler, Kathryn E Hentges
Publicado 2017

COVID-19 vaccination in Sindh Province, Pakistan: A modelling study of health impact and cost-effectiveness.

por Carl A B Pearson, Fiammetta Bozzani, Simon R Procter, Nicholas G Davies, Maryam Huda, Henning Tarp Jensen, Marcus Keogh-Brown, Muhammad Khalid, Sedona Sweeney, Sergio Torres-Rueda, CHiL COVID-19 Working Group, CMMID COVID-19 Working Group, Rosalind M Eggo, Anna Vassall, Mark Jit
Publicado 2021

High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine...

por Laura Sibley, Andrew D. White, Karen E. Gooch, Lisa M. Stevens, Rachel Tanner, Ashley Jacobs, Owen Daykin-Pont, Fergus Gleeson, Anthony McIntyre, Randall Basaraba, Simon Clark, Graham Hall, Geoff Pearson, Emma Rayner, Helen McShane, Ann Williams, Mike Dennis, Philip D. Marsh, Sally Sharpe
Publicado 2021