Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

por Maximilian Strunz, Lukas M. Simon, Meshal Ansari, Jaymin J. Kathiriya, Ilias Angelidis, Christoph H. Mayr, George Tsidiridis, Marius Lange, Laura F. Mattner, Min Yee, Paulina Ogar, Arunima Sengupta, Igor Kukhtevich, Robert Schneider, Zhongming Zhao, Carola Voss, Tobias Stoeger, Jens H. L. Neumann, Anne Hilgendorff, Jürgen Behr, Michael O’Reilly, Mareike Lehmann, Gerald Burgstaller, Melanie Königshoff, Harold A. Chapman, Fabian J. Theis, Herbert B. Schiller
Publicado 2020

Resequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil

por Yun-Peng Zhao, Guangyi Fan, Ping-Ping Yin, Shuai Sun, Ning Li, Xiaoning Hong, Gang Hu, He Zhang, Fu-Min Zhang, Jing-Dan Han, Ya-Jun Hao, Qiwu Xu, Xianwei Yang, Wenjie Xia, Wenbin Chen, Han-Yang Lin, Rui Zhang, Jiang Chen, Xiao-Ming Zheng, Simon Ming-Yuen Lee, Joongku Lee, Koichi Uehara, Jian Wang, Huanming Yang, Cheng-Xin Fu, Xin Liu, Xun Xu, Song Ge
Publicado 2019

78,000-year-old record of Middle and Later Stone Age innovation in an East African tropical forest

por Ceri Shipton, Patrick Roberts, Will Archer, Simon J. Armitage, Caesar Bita, James Blinkhorn, Colin Courtney-Mustaphi, Alison Crowther, Richard Curtis, Francesco d’ Errico, Katerina Douka, Patrick Faulkner, Huw S. Groucutt, Richard Helm, Andy I. R Herries, Severinus Jembe, Nikos Kourampas, Julia Lee-Thorp, Rob Marchant, Julio Mercader, Africa Pitarch Marti, Mary E. Prendergast, Ben Rowson, Amini Tengeza, Ruth Tibesasa, Tom S. White, Michael D. Petraglia, Nicole Boivin
Publicado 2018

Transplantation of discarded livers following viability testing with normothermic machine perfusion

por Hynek Mergental, Richard W. Laing, Amanda J. Kirkham, M. Thamara P. R. Perera, Yuri L. Boteon, Joseph Attard, Darren Barton, Stuart Curbishley, Manpreet Wilkhu, Desley A. H. Neil, Stefan G. Hübscher, Paolo Muiesan, John R. Isaac, Keith J. Roberts, Manuel Abradelo, Andrea Schlegel, James Ferguson, Hentie Cilliers, Julian Bion, David H. Adams, Chris Morris, Peter J. Friend, Christina Yap, Simon C. Afford, Darius F. Mirza
Publicado 2020

Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion

por David Simon, Koray Tascilar, Gerhard Krönke, Arnd Kleyer, Mario M. Zaiss, Franz Heppt, Christine Meder, Raja Atreya, Entcho Klenske, Peter Dietrich, Abdullah Abdullah, Thorsten Kliem, Giulia Corte, Harriet Morf, Moritz Leppkes, Andreas E. Kremer, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Clara Maier, Axel J. Hueber, Karin Manger, Bernhard Manger, Carola Berking, Matthias Tenbusch, Klaus Überla, Michael Sticherling, Markus F. Neurath, Georg Schett
Publicado 2020

Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes

por Valeriy Domenyuk, Zoran Gatalica, Radhika Santhanam, Xixi Wei, Adam Stark, Patrick Kennedy, Brandon Toussaint, Symon Levenberg, Jie Wang, Nianqing Xiao, Richard Greil, Gabriel Rinnerthaler, Simon P. Gampenrieder, Amy B. Heimberger, Donald A. Berry, Anna Barker, John Quackenbush, John L. Marshall, George Poste, Jeffrey L. Vacirca, Gregory A. Vidal, Lee S. Schwartzberg, David D. Halbert, Andreas Voss, Daniel Magee, Mark R. Miglarese, Michael Famulok, Günter Mayer, David Spetzler
Publicado 2018

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

por Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord
Publicado 2021

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

por Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L. Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor
Publicado 2020

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

por Søs Grønbæk Holdgaard, Valentina Cianfanelli, Emanuela Pupo, Matteo Lambrughi, Michal Lubas, Julie C. Nielsen, Susana Eibes, Emiliano Maiani, Lea M. Harder, Nicole Wesch, Mads Møller Foged, Kenji Maeda, Francesca Nazio, Laura R. de la Ballina, Volker Dötsch, Andreas Brech, Lisa B. Frankel, Marja Jäättelä, Franco Locatelli, Marin Barisic, Jens S. Andersen, Simon Bekker-Jensen, Anders H. Lund, Vladimir V. Rogov, Elena Papaleo, Letizia Lanzetti, Daniela De Zio, Francesco Cecconi
Publicado 2019

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

por Jacqueline H. L. Fok, Antonio Ramos-Montoya, Mercedes Vazquez-Chantada, Paul W. G. Wijnhoven, Valeria Follia, Neil James, Paul M. Farrington, Ankur Karmokar, Sophie E. Willis, Jonathan Cairns, Jenni Nikkilä, David Beattie, Gillian M. Lamont, M. Raymond V. Finlay, Joanne Wilson, Aaron Smith, Lenka Oplustil O’Connor, Stephanie Ling, Stephen E. Fawell, Mark J. O’Connor, Simon J. Hollingsworth, Emma Dean, Frederick W. Goldberg, Barry R. Davies, Elaine B. Cadogan
Publicado 2019

βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity

por Sayan Ghosh, Haitao Liu, Meysam Yazdankhah, Nadezda Stepicheva, Peng Shang, Tanuja Vaidya, Stacey Hose, Urvi Gupta, Michael Joseph Calderon, Ming-Wen Hu, Archana Padmanabhan Nair, Joseph Weiss, Christopher S. Fitting, Imran A. Bhutto, Santosh Gopi Krishna Gadde, Naveen Kumar Naik, Chaitra Jaydev, Gerard A. Lutty, James T. Handa, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, Dhivyaa Rajasundaram, Yuri Sergeev, J. Samuel Zigler, Swaminathan Sethu, Simon Watkins, Arkasubhra Ghosh, Debasish Sinha
Publicado 2021

Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling

por Icia Santos-Zas, Jeremie Lemarié, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bizé, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, José Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sébastien Silvestre, Hafid Ait-Oufella
Publicado 2021

B cell zone reticular cell microenvironments shape CXCL13 gradient formation

por Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Publicado 2020

Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel DiseaseSummary

por Ahmad A. Al-Shaibi, Ussama M. Abdel-Motal, Satanay Z. Hubrack, Alex N. Bullock, Amna A. Al-Marri, Nourhen Agrebi, Abdulrahman A. Al-Subaiey, Nazira A. Ibrahim, Adrian K. Charles, Mamoun Elawad, Holm H. Uhlig, Bernice Lo, Saad R. Al-Kaabi, Muneera J. Al-Mohannadi, Fayaz A. Mir, Holm H. Uhlig, Simon P.L. Travis, Mamoun Elawad, Anthony K. Akobeng, Nazira A. Ibrahim, Fatma Al-Mudahka, Bernice Lo
Publicado 2021

Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models

por Anny Devoy, Georgia Price, Francesca De Giorgio, Rosie Bunton-Stasyshyn, David Thompson, Samanta Gasco, Alasdair Allan, Gemma F. Codner, Remya R. Nair, Charlotte Tibbit, Ross McLeod, Zeinab Ali, Judith Noda, Alessandro Marrero-Gagliardi, José M. Brito-Armas, Muhammet M. Öztürk, Michelle Simon, Edward O'Neill, Sam Bryce-Smith, Jackie Harrison, Gemma Atkins, Silvia Corrochano, Michelle Stewart, Lydia Teboul, Abraham Acevedo-Arozena, Elizabeth M.C. Fisher, Thomas J. Cunningham
Publicado 2021

Special Low Protein Foods Prescribed in England for PKU Patients: An Analysis of Prescribing Patterns and Cost

por Georgina Wood, Alex Pinto, Sharon Evans, Anne Daly, Sandra Adams, Susie Costelloe, Joanna Gribben, Charlotte Ellerton, Anita Emm, Sarah Firman, Suzanne Ford, Moira French, Lisa Gaff, Emily Giuliano, Melanie Hill, Inderdip Hunjan, Camille Newby, Allison Mackenzie, Rachel Pereira, Celine Prescott, Louise Robertson, Heidi Seabert, Rachel Skeath, Simon Tapley, Allyson Terry, Alison Tooke, Karen van Wyk, Fiona J. White, Lucy White, Alison Woodall, Júlio César Rocha, Anita MacDonald
Publicado 2021

Correction: Corrigendum: Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis

por Phelim Bradley, N. Claire Gordon, Timothy M. Walker, Laura Dunn, Simon Heys, Bill Huang, Sarah Earle, Louise J. Pankhurst, Luke Anson, Mariateresa de Cesare, Paolo Piazza, Antonina A. Votintseva, Tanya Golubchik, Daniel J. Wilson, David H. Wyllie, Roland Diel, Stefan Niemann, Silke Feuerriegel, Thomas A. Kohl, Nazir Ismail, Shaheed V. Omar, E. Grace Smith, David Buck, Gil McVean, A. Sarah Walker, Tim E. A. Peto, Derrick W. Crook, Zamin Iqbal
Publicado 2016

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

por Mohammad Asim, Firas Tarish, Heather I. Zecchini, Kumar Sanjiv, Eleni Gelali, Charles E. Massie, Ajoeb Baridi, Anne Y. Warren, Wanfeng Zhao, Christoph Ogris, Leigh-Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul Wijnhoven, Josep V. Forment, Scott R. Lyons, Andy G. Lynch, Cormac O’Neill, Vincent R. Zecchini, Paul S. Rennie, Aria Baniahmad, Simon Tavaré, Ian G. Mills, Yaron Galanty, Nicola Crosetto, Niklas Schultz, David Neal, Thomas Helleday
Publicado 2017

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

por Tom J. Phillips, Hannah Scott, David A. Menassa, Ashleigh L. Bignell, Aman Sood, Jude S. Morton, Takami Akagi, Koki Azuma, Mark F. Rogers, Catherine E. Gilmore, Gareth J. Inman, Simon Grant, Yealin Chung, Mais M. Aljunaidy, Christy-Lynn Cooke, Bruno R. Steinkraus, Andrew Pocklington, Angela Logan, Gavin P. Collett, Helena Kemp, Peter A. Holmans, Michael P. Murphy, Tudor A. Fulga, Andrew M. Coney, Mitsuru Akashi, Sandra T. Davidge, C. Patrick Case
Publicado 2017

Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors

por Luca Urbani, Carlotta Camilli, Demetra-Ellie Phylactopoulos, Claire Crowley, Dipa Natarajan, Federico Scottoni, Panayiotis Maghsoudlou, Conor J. McCann, Alessandro Filippo Pellegata, Anna Urciuolo, Koichi Deguchi, Sahira Khalaf, Salvatore Ferdinando Aruta, Maria Cristina Signorelli, David Kiely, Edward Hannon, Matteo Trevisan, Rui Rachel Wong, Marc Olivier Baradez, Dale Moulding, Alex Virasami, Asllan Gjinovci, Stavros Loukogeorgakis, Sara Mantero, Nikhil Thapar, Neil Sebire, Simon Eaton, Mark Lowdell, Giulio Cossu, Paola Bonfanti, Paolo De Coppi
Publicado 2018