Structure-based insights into evolution of rhodopsins

por Dmitrii Zabelskii, Natalia Dmitrieva, Oleksandr Volkov, Vitaly Shevchenko, Kirill Kovalev, Taras Balandin, Dmytro Soloviov, Roman Astashkin, Egor Zinovev, Alexey Alekseev, Ekaterina Round, Vitaly Polovinkin, Igor Chizhov, Andrey Rogachev, Ivan Okhrimenko, Valentin Borshchevskiy, Vladimir Chupin, Georg Büldt, Natalia Yutin, Ernst Bamberg, Eugene Koonin, Valentin Gordeliy
Publicado 2021

Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival

por Megumi Nishinaga, Hiroshi Sugimoto, Yudai Nishitani, Seina Nagai, Satoru Nagatoishi, Norifumi Muraki, Takehiko Tosha, Kouhei Tsumoto, Shigetoshi Aono, Yoshitsugu Shiro, Hitomi Sawai
Publicado 2021

IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice

por Carolin K. Koss, Christian T. Wohnhaas, Jonathan R. Baker, Cornelia Tilp, Michèl Przibilla, Carmen Lerner, Silvia Frey, Martina Keck, Cara M. M. Williams, Daniel Peter, Meera Ramanujam, Jay Fine, Florian Gantner, Matthew Thomas, Peter J. Barnes, Louise E. Donnelly, Karim C. El Kasmi
Publicado 2021

Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses

por Nishant Singh, Thomas Bartol, Herbert Levine, Terrence Sejnowski, Suhita Nadkarni
Publicado 2021

CryoET structures of immature HIV Gag reveal six-helix bundle

por Luiza Mendonça, Dapeng Sun, Jiying Ning, Jiwei Liu, Abhay Kotecha, Mateusz Olek, Thomas Frosio, Xiaofeng Fu, Benjamin A. Himes, Alex B. Kleinpeter, Eric O. Freed, Jing Zhou, Christopher Aiken, Peijun Zhang
Publicado 2021

Iron induces two distinct Ca2+ signalling cascades in astrocytes

por Wenzheng Guan, Maosheng Xia, Ming Ji, Beina Chen, Shuai Li, Manman Zhang, Shanshan Liang, Binjie Chen, Wenliang Gong, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Dianjun Zhang, Xinyu Li, Yuefei Zhou, Dawei Guan, Alexei Verkhratsky, Baoman Li
Publicado 2021

Impact of Rap-Phr system abundance on adaptation of Bacillus subtilis

por Ramses Gallegos-Monterrosa, Mathilde Nordgaard Christensen, Tino Barchewitz, Sonja Koppenhöfer, B. Priyadarshini, Balázs Bálint, Gergely Maróti, Paul J. Kempen, Anna Dragoš, Ákos T. Kovács
Publicado 2021

pH-dependent and dynamic interactions of cystatin C with heparan sulfate

por Xiaoxiao Zhang, Xinyue Liu, Guowei Su, Miaomiao Li, Jian Liu, Chunyu Wang, Ding Xu
Publicado 2021

Global mapping of protein–metabolite interactions in Saccharomyces cerevisiae reveals that Ser-Leu dipeptide regulates phosphoglycerate kinase activity

por Marcin Luzarowski, Rubén Vicente, Andrei Kiselev, Mateusz Wagner, Dennis Schlossarek, Alexander Erban, Leonardo Perez de Souza, Dorothee Childs, Izabela Wojciechowska, Urszula Luzarowska, Michał Górka, Ewelina M. Sokołowska, Monika Kosmacz, Juan C. Moreno, Aleksandra Brzezińska, Bhavana Vegesna, Joachim Kopka, Alisdair R. Fernie, Lothar Willmitzer, Jennifer C. Ewald, Aleksandra Skirycz
Publicado 2021

Midgut development in rat embryos using microcomputed tomography

por Marco Ginzel, Illya Martynov, Rainer Haak, Martin Lacher, Dietrich Kluth
Publicado 2021

High-throughput screening and validation of antibodies against synaptic proteins to explore opioid signaling dynamics

por Mariana Lemos Duarte, Nikita A. Trimbake, Achla Gupta, Christine Tumanut, Xiaomin Fan, Catherine Woods, Akila Ram, Ivone Gomes, Erin N. Bobeck, Deborah Schechtman, Lakshmi A. Devi
Publicado 2021

Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes

por Alena Ivashenka, Christian Wunder, Valerie Chambon, Roger Sandhoff, Richard Jennemann, Estelle Dransart, Katrina Podsypanina, Bérangère Lombard, Damarys Loew, Christophe Lamaze, Francoise Poirier, Hermann-Josef Gröne, Ludger Johannes, Massiullah Shafaq-Zadah
Publicado 2021

Pharmacological inactivation of the prion protein by targeting a folding intermediate

por Giovanni Spagnolli, Tania Massignan, Andrea Astolfi, Silvia Biggi, Marta Rigoli, Paolo Brunelli, Michela Libergoli, Alan Ianeselli, Simone Orioli, Alberto Boldrini, Luca Terruzzi, Valerio Bonaldo, Giulia Maietta, Nuria L. Lorenzo, Leticia C. Fernandez, Yaiza B. Codeseira, Laura Tosatto, Luise Linsenmeier, Beatrice Vignoli, Gianluca Petris, Dino Gasparotto, Maria Pennuto, Graziano Guella, Marco Canossa, Hermann C. Altmeppen, Graziano Lolli, Stefano Biressi, Manuel M. Pastor, Jesús R. Requena, Ines Mancini, Maria L. Barreca, Pietro Faccioli, Emiliano Biasini
Publicado 2021

Simple sequence repeats drive genome plasticity and promote adaptive evolution in penaeid shrimp

por Jianbo Yuan, Xiaojun Zhang, Min Wang, Yamin Sun, Chengzhang Liu, Shihao Li, Yang Yu, Yi Gao, Fei Liu, Xiaoxi Zhang, Jie Kong, Guangyi Fan, Chengsong Zhang, Lu Feng, Jianhai Xiang, Fuhua Li
Publicado 2021

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

por Youngchang Kim, Jacek Wower, Natalia Maltseva, Changsoo Chang, Robert Jedrzejczak, Mateusz Wilamowski, Soowon Kang, Vlad Nicolaescu, Glenn Randall, Karolina Michalska, Andrzej Joachimiak
Publicado 2021

Inference of phenotype-relevant transcriptional regulatory networks elucidates cancer type-specific regulatory mechanisms in a pan-cancer study

por Amin Emad, Saurabh Sinha
Publicado 2021

Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression

por Chisato Kinoshita, Kazue Kikuchi-Utsumi, Koji Aoyama, Ryo Suzuki, Yayoi Okamoto, Nobuko Matsumura, Daiki Omata, Kazuo Maruyama, Toshio Nakaki
Publicado 2021

A novel canine reference genome resolves genomic architecture and uncovers transcript complexity

por Chao Wang, Ola Wallerman, Maja-Louise Arendt, Elisabeth Sundström, Åsa Karlsson, Jessika Nordin, Suvi Mäkeläinen, Gerli Rosengren Pielberg, Jeanette Hanson, Åsa Ohlsson, Sara Saellström, Henrik Rönnberg, Ingrid Ljungvall, Jens Häggström, Tomas F. Bergström, Åke Hedhammar, Jennifer R. S. Meadows, Kerstin Lindblad-Toh
Publicado 2021

Bridgehead effect and multiple introductions shape the global invasion history of a termite

por Alexander J. Blumenfeld, Pierre-André Eyer, Claudia Husseneder, Jianchu Mo, Laura N. L. Johnson, Changlu Wang, J. Kenneth Grace, Thomas Chouvenc, Shichen Wang, Edward L. Vargo
Publicado 2021

CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6

por Yohei Maruyama, Mitsuhiro Sugawa, Shin Yamaguchi, Tim Davies, Toshihisa Osaki, Takuya Kobayashi, Masahiko Yamagishi, Shoji Takeuchi, Masanori Mishima, Junichiro Yajima
Publicado 2021