mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

por Benedetta De Ponte Conti, Annarita Miluzio, Fabio Grassi, Sergio Abrignani, Stefano Biffo, Sara Ricciardi
Publicado 2021

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses

por John Lee, Kosuke Kawai, Jeffrey R Holt, Gwenaëlle SG Géléoc
Publicado 2021

The discriminatory power of the T cell receptor

por Johannes Pettmann, Anna Huhn, Enas Abu Shah, Mikhail A Kutuzov, Daniel B Wilson, Michael L Dustin, Simon J Davis, P Anton van der Merwe, Omer Dushek
Publicado 2021

Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

por Sarah G Swygert, Dejun Lin, Stephanie Portillo-Ledesma, Po-Yen Lin, Dakota R Hunt, Cheng-Fu Kao, Tamar Schlick, William S Noble, Toshio Tsukiyama
Publicado 2021

Quantifying the relationship between SARS-CoV-2 viral load and infectiousness

por Aurélien Marc, Marion Kerioui, François Blanquart, Julie Bertrand, Oriol Mitjà, Marc Corbacho-Monné, Michael Marks, Jeremie Guedj
Publicado 2021

A causal role for the right frontal eye fields in value comparison

por Ian Krajbich, Andres Mitsumasu, Rafael Polania, Christian C Ruff, Ernst Fehr
Publicado 2021

Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis

por Maren Kasper, Michael Heming, David Schafflick, Xiaolin Li, Tobias Lautwein, Melissa Meyer zu Horste, Dirk Bauer, Karoline Walscheid, Heinz Wiendl, Karin Loser, Arnd Heiligenhaus, Gerd Meyer zu Hörste
Publicado 2021

Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway

por Lianna W Wat, Zahid S Chowdhury, Jason W Millington, Puja Biswas, Elizabeth J Rideout
Publicado 2021

A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation

por Jie Wang, Amir Rattner, Jeremy Nathans
Publicado 2021

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

por Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, Maria Sladowska, Michal Turek, Barbara Uszczynska-Ratajczak, Rishika Kundra, Tomasz Goral, Michele Perni, Christopher M Dobson, Michele Vendruscolo, Agnieszka Chacinska
Publicado 2021

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

por Suhong Sun, Shuting Li, Zhengnan Luo, Minhui Ren, Shunji He, Guangqin Wang, Zhiyong Liu
Publicado 2021

Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

por Thomas P Burke, Patrik Engström, Cuong J Tran, Ingeborg M Langohr, Dustin R Glasner, Diego A Espinosa, Eva Harris, Matthew D Welch
Publicado 2021

STING mediates immune responses in the closest living relatives of animals

por Arielle Woznica, Ashwani Kumar, Carolyn R Sturge, Chao Xing, Nicole King, Julie K Pfeiffer
Publicado 2021

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation

por Teresa Romeo Luperchio, Leandros Boukas, Li Zhang, Genay Pilarowski, Jenny Jiang, Allison Kalinousky, Kasper D Hansen, Hans T Bjornsson
Publicado 2021

Heterogeneous side effects of cortical inactivation in behaving animals

por Ariana R Andrei, Samantha Debes, Mircea Chelaru, Xiaoqin Liu, Elsa Rodarte, John L Spudich, Roger Janz, Valentin Dragoi
Publicado 2021

Ciliary Hedgehog signaling regulates cell survival to build the facial midline

por Shaun R Abrams, Jeremy F Reiter
Publicado 2021

Task-specific roles of local interneurons for inter- and intraglomerular signaling in the insect antennal lobe

por Debora Fusca, Peter Kloppenburg
Publicado 2021

Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

por Konstantinos Gkatzis, Paolo Panza, Sofia Peruzzo, Didier YR Stainier
Publicado 2021

Human embryo polarization requires PLC signaling to mediate trophectoderm specification

por Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Publicado 2021

The structure of behavioral variation within a genotype

por Zachary Werkhoven, Alyssa Bravin, Kyobi Skutt-Kakaria, Pablo Reimers, Luisa F Pallares, Julien Ayroles, Benjamin L de Bivort
Publicado 2021