Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing

by Rebecca S. Shapiro, Leah E. Cowen
Published 2012

The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling

by Saif Hossain, Amanda O. Veri, Leah E. Cowen
Published 2020

A functionally divergent intrinsically disordered region underlying the conservation of stochastic signaling.

by Ian S Hsu, Bob Strome, Emma Lash, Nicole Robbins, Leah E Cowen, Alan M Moses
Published 2021

Staurosporine Induces Filamentation in the Human Fungal Pathogen <named-content content-type="genus-species">Candida albicans</named-content> via Signaling through Cyr1 and Protein...

by Jinglin L. Xie, Teresa R. O’Meara, Elizabeth J. Polvi, Nicole Robbins, Leah E. Cowen
Published 2017

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.

by Michelle D Leach, Susan Budge, Louise Walker, Carol Munro, Leah E Cowen, Alistair J P Brown
Published 2012

Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen <named-content content-type="genus-species">Candida auris</name...

by Kali R. Iyer, Luke Whitesell, John A. Porco, Thomas Henkel, Lauren E. Brown, Nicole Robbins, Leah E. Cowen
Published 2020

Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic <italic toggle="yes">Candida</italic> Species

by Nicole M. Revie, Nicole Robbins, Luke Whitesell, John R. Frost, Solomon D. Appavoo, Andrei K. Yudin, Leah E. Cowen
Published 2020

Erratum for Kim et al., “Genetic Analysis of <named-content content-type="genus-species">Candida auris</named-content> Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr...

by Sang Hu Kim, Kali R. Iyer, Lakhansing Pardeshi, José F. Muñoz, Nicole Robbins, Christina A. Cuomo, Koon Ho Wong, Leah E. Cowen
Published 2019

Genetic Analysis of <italic toggle="yes">Candida auris</italic> Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance

by Sang Hu Kim, Kali R. Iyer, Lakhansing Pardeshi, José F. Muñoz, Nicole Robbins, Christina A. Cuomo, Koon Ho Wong, Leah E. Cowen
Published 2019

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

by Michelle D. Leach, Rhys A. Farrer, Kaeling Tan, Zhengqiang Miao, Louise A. Walker, Christina A. Cuomo, Robert T. Wheeler, Alistair J. P. Brown, Koon Ho Wong, Leah E. Cowen
Published 2016

High-Throughput Screening Identifies Genes Required for <italic toggle="yes">Candida albicans</italic> Induction of Macrophage Pyroptosis

by Teresa R. O’Meara, Kwamaa Duah, Cynthia X. Guo, Michelle E. Maxson, Ryan G. Gaudet, Kristy Koselny, Melanie Wellington, Michael E. Powers, Jessie MacAlpine, Matthew J. O’Meara, Amanda O. Veri, Sergio Grinstein, Suzanne M. Noble, Damian Krysan, Scott D. Gray-Owen, Leah E. Cowen
Published 2018

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

by Jinglin L. Xie, Longguang Qin, Zhengqiang Miao, Ben T. Grys, Jacinto De La Cruz Diaz, Kenneth Ting, Jonathan R. Krieger, Jiefei Tong, Kaeling Tan, Michelle D. Leach, Troy Ketela, Michael F. Moran, Damian J. Krysan, Charles Boone, Brenda J. Andrews, Anna Selmecki, Koon Ho Wong, Nicole Robbins, Leah E. Cowen
Published 2017

Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture

by Matthew C. Fisher, Sarah J. Gurr, Christina A. Cuomo, David S. Blehert, Hailing Jin, Eva H. Stukenbrock, Jason E. Stajich, Regine Kahmann, Charles Boone, David W. Denning, Neil A. R. Gow, Bruce S. Klein, James W. Kronstad, Donald C. Sheppard, John W. Taylor, Gerard D. Wright, Joseph Heitman, Arturo Casadevall, Leah E. Cowen
Published 2020

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

by Luke Whitesell, Nicole Robbins, David S. Huang, Catherine A. McLellan, Tanvi Shekhar-Guturja, Emmanuelle V. LeBlanc, Catherine S. Nation, Raymond Hui, Ashley Hutchinson, Cathy Collins, Sharanya Chatterjee, Richard Trilles, Jinglin L. Xie, Damian J. Krysan, Susan Lindquist, John A. Porco, Utpal Tatu, Lauren E. Brown, Juan Pizarro, Leah E. Cowen
Published 2019

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

by Kali R. Iyer, Kaddy Camara, Martin Daniel-Ivad, Richard Trilles, Sheila M. Pimentel-Elardo, Jen L. Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, José F. Muñoz, Sang Hu Kim, John A. Porco, Christina A. Cuomo, Noelle S. Williams, Ashraf S. Ibrahim, John E. Edwards, David R. Andes, Justin R. Nodwell, Lauren E. Brown, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Published 2020

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets

by Ci Fu, Xiang Zhang, Amanda O. Veri, Kali R. Iyer, Emma Lash, Alice Xue, Huijuan Yan, Nicole M. Revie, Cassandra Wong, Zhen-Yuan Lin, Elizabeth J. Polvi, Sean D. Liston, Benjamin VanderSluis, Jing Hou, Yoko Yashiroda, Anne-Claude Gingras, Charles Boone, Teresa R. O’Meara, Matthew J. O’Meara, Suzanne Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Published 2021