Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2

Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2

ABSTRACT Globally, more antimicrobials are used in food-producing animals than in humans, and the extensive use of medically important human antimicrobials poses a significant public health threat in the face of rising antimicrobial resistance (AMR). The development of novel ionophores, a class of a...

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Main Authors: Nichaela Harbison-Price, Scott A. Ferguson, Adam Heikal, George Taiaroa, Kiel Hards, Yoshio Nakatani, David Rennison, Margaret A. Brimble, Ibrahim M. El-Deeb, Lisa Bohlmann, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker, Gregory M. Cook
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
antimicrobial resistance
PBT2
zinc
manganese
ionophore
metal ion homeostasis
Microbiology
QR1-502
Online Access:https://doaj.org/article/7ba6568165cb4f2489d265bf769ffb42
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https://doaj.org/article/7ba6568165cb4f2489d265bf769ffb42

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